摘要
目的 研究曼月乐与黄体酮治疗围绝经期异常子宫出血的疗效及对性激素水平的影响。方法 回顾性选取福建省南平市妇幼保健院2017年5月-2021年5月期间收治的84例围绝经期异常子宫出血患者进行研究,按治疗差异分为对照组和研究组,每组42例。对照组采取黄体酮治疗,研究组实施曼月乐实施。对比两组治疗总有效率、月经情况、子宫内膜厚度、激素水平、血红蛋白(Hb)及红细胞比容(Hct)水平、不良反应情况。结果 研究组治疗总有效率95.24%高于对照组78.57%,研究组治疗期间不良反应发生率2.38%低于对照组19.05%,差异有统计学意义(χ^(2)=5.126、4.480,P<0.05);治疗3个月两组月经量、经期时间、子宫内膜厚度对比差异有统计学意义(P<0.05);治疗3个月研究组激素LH、FSH、E_(2)、P水平低于对照组,Hb、Hct水平高于对照组,差异有统计学意义(P<0.05)。结论 围绝经期异常子宫出血使用曼月乐治疗后,可有效改善患者激素水平,使得患者月经量减少,改善贫血状况,整体治疗效果理想,值得临床应用。
Objective To study the effect of Mirena and progesterone on perimenopausal abnormal uterine bleeding and sex hormone levels.Methods A retrospective study was conducted on 84 patients with perimenopausal abnormal uterine bleeding who were admitted to Nanping Maternal and Child Health Hospital of Fujian Province from May 2017 to May 2021.They were divided into control group and study group according to treatment differences,with 42 cases in each group.The control group was treated with progesterone,and the study group was treated with Mirena.The total effective rate,menstrual status,endometrial thickness,hormone level,hemoglobin(Hb),hematocrit(Hct)level and adverse reactions were compared between the two groups.Results The incidence of total effective rate of treatment in the study group was 95.24%higher than that in the control group(78.57%),the adverse reactions in the study group were 2.38%lower than those in the control group(19.05%).The difference was statistically significant(χ^(2)=5.126,4.480,P<0.05);there were statistically significant differences in menstrual volume,menstrual period and endometrial thickness between the two groups after 3 months of treatment(P<0.05).After 3 months of treatment,the levels of LH,FSH,E_(2),and P in the study group were lower than those in the control group,the levels of Hb and Hct were higher than those in the control group,and the differences were statistically significant(P<0.05).Conclusion After the treatment of abnormal uterine bleeding in perimenopause,Mirena can effectively improve the hormone level of patients,reduce the menstrual volume of patients and improve anemia.The overall therapeutic effect is ideal,worthy of clinical application.
作者
马慧冰
MA Huibing(Department of Obstetrics and Gynecology,Nanping Maternal and Child Health Care Hospital,Nanping,Fujian Province,353000 China)
出处
《中外医疗》
2022年第34期121-124,133,共5页
China & Foreign Medical Treatment
关键词
曼月乐
黄体酮
围绝经期异常子宫出血
疗效
性激素
Mirena
Progesterone
Abnormal uterine bleeding in perimenopause
Curative effect
Sex hormone
