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老年男性血清尿酸水平与局部肌肉含量的相关性

Association between serum uric acid and local muscle mass in elderly males
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摘要 目的探讨老年男性局部肌肉含量与血清尿酸水平之间的相关性,为临床肌少症的预防与治疗提供新的观点和依据。方法选择2019年1月至2021年12月于南京大学医学院附属鼓楼医院老年科治疗的350例60岁及以上男性患者为研究对象,根据尿酸水平将患者分为Q1、Q2、Q3、Q4组,四分位切点分别为0~<320、320~<360、360~<420、≥420μmol/L,对4组间髋部肌肉和脊柱肌肉占比、血脂等进行比较。采用SPSS 20.0统计软件进行数据分析。根据数据类型,采用非参数Kruskal-Wallis H检验进行组间比较。校正年龄、体质量指数、血脂等混杂因素后,用偏相关分析对血清尿酸水平与局部肌肉含量进行相关性分析。结果随着尿酸水平的升高,Q4组胆固醇、甘油三酯、肌酐水平均明显升高,差异有统计学意义(P<0.05)。4组患者髋部肌肉含量比较,差异无统计学意义(P=0.641),尿酸水平与髋部肌肉在总体趋势方面呈现“反J”型。脊柱肌肉含量方面,Q4组明显低于Q1组(P=0.024)。在Q4组,髋部肌肉含量与尿酸水平呈明显负相关(r=-0.239,P=0.006)。脊柱肌肉含量与尿酸水平在4组均未表现有明显的相关性。结论60岁及以上的老年男性,高尿酸血症可导致局部肌肉含量,尤其是髋部肌肉含量的减少。为帮助维持骨骼肌质量及髋部肌肉含量,建议维持理想的尿酸水平,将尿酸水平控制在420μmol/L以下。 Objective To explore the association of serum uric acid(UA)with local muscle mass in the elderly males in a view to providing a new perspective and basis for the prevention and control of sarcopenia.Methods A total of 350 males aged 60 years and over in the Department of Geriatrics in Affiliated Hospital of Nanjing University Medical School from January 2019 to December 2021 were selected as subjects.According to serum UA,they were divided into four groups:Q1(0-<320μmol/L),Q2(320-<360μmol/L),Q3(360-<420μmol/L),and Q4(≥420μmol/L)(Q=quadrant).The four groups were compared in the muscle percentiles of the hip and spine,and blood lipids.SPSS statistics 20.0 was used for data analysis.According to data type,comparison between groups was performed using Nonparametric Kruskal-Wallis H test.After adjusting for age,body mass index,blood lipid and other confounding factors,partial correlation was used to analyze the correlation between serum UA and local muscle mass.Results With higher UA,total cholesterol,triglyceride,serum creatinine increased significantly in Q4 group(P<0.05).There was no significant difference in the hip muscle mass between the four groups(P=0.641),and serum UA levels showed a reverse J-shaped curve with hip muscle mass.Pinal muscle mass in the Q4 group was significantly lower than that in the Q1 group(P=0.024).There was a significant negative correlation between UA level and the hip muscle mass in the Q4 group(r=-0.239,P=0.006),but no correlation was found between UA and the waist muscle mass in the same group.Conclusion Hyperuricemia can cause a decrease in local muscle mass,especially of the hip,in the males aged 60 years or over.It is advised to keep serum UA at an optimal level(UA<420μmol/L)to help maintain skeletal muscle mass and hip muscle percentile.
作者 孙婧 杨帆 杨立 Sun Jing;Yang Fan;Yang Li(Department of Geriatrics,Affiliated Hospital of Nanjing University Medical School,Nanjing 210008,China)
出处 《中华老年多器官疾病杂志》 2023年第4期280-283,共4页 Chinese Journal of Multiple Organ Diseases in the Elderly
关键词 老年人 男性 血清尿酸 肌肉含量 aged males serum uric acid muscle mass
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