摘要
目的观察芪参益气滴丸对冠心病经皮冠状动脉介入治疗(PCI)术后合并抑郁患者的临床疗效。方法将行冠心病PCI术后合并抑郁患者100例采用随机数字表法分为对照组和治疗组,各50例。对照组患者在PCI术后予以西医常规药物进行治疗,并给予心理疏导;治疗组在此基础上加用芪参益气滴丸治疗,0.5 g/次,3次/d。2组均治疗4周。观察患者心功能相关指标、中医证候疗效和抑郁情绪改善情况。结果治疗前2组左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)差异无统计学意义,治疗后2组LVEF均较治疗前升高,LVEDD降低(P<0.05),且治疗组的LVEF高于对照组,而LVEDD低于对照组(P<0.05)。在中医证候疗效方面,治疗组总有效率高于对照组(92.0%vs.76.0%,χ^(2)=4.762,P<0.05)。治疗前2组汉密尔顿抑郁量表17项(HAMD-17)评分差异无统计学意义;治疗后2组HAMD-17评分均较治疗前降低(P<0.05),且治疗组HAMD-17评分低于对照组(P<0.05)。治疗组的抑郁情绪治疗总有效率高于对照组(90.0%vs.74.0%,χ^(2)=4.336,P<0.05)。结论芪参益气滴丸既可以改善患者心肌血供,也能有效改善患者的心理状态,缓解患者的抑郁情绪。
Objective To observe the effect of Qishen Yiqi dropping pill on prognosis of patients with coronary heart disease complicated with depression after percutaneous coronary intervention(PCI).Methods A total of 100 patients with coronary heart disease complicated with depression who underwent PCI were divided into the control group and the treatment group by random number table method,with 50 cases in each group.Patients of the control group were treated with conventional Western medicine and psychological counseling after PCI.The treatment group was additionally treated with Qishen Yiqi dropping pill,0.5 g each time,3 times a day.Both groups were treated for 4 weeks.The cardiac function related indicators were observed in patients of the two groups.The efficacy of the traditional Chinese medicine(TCM)syndrome and depression mood improvement were also observed.Results Before treatment,there were no significant differences in left ventricular ejection fraction(LVEF)and left ventricular end-diastolic diameter(LVEDD)between the two groups.After treatment,LVEF was higher in both groups than that before treatment,while LVEDD was lower(P<0.05).LVEF was significantly higher in the treatment group than that in the control group,while LVEDD was lower(P<0.05).In terms of curative effect of TCM syndromes,the total effective rate was higher in the treatment group than that of the control group(92.0%vs.76.0%,χ^(2)=4.762,P<0.05).Before treatment,there was no significant difference in HAMD-17 score between the two groups.After treatment,HAMD-17 score was lower than that before treatment in both groups(P<0.05),and HAMD-17 score was significantly lower in the treatment group than that in the control group(P<0.05).The effective rate of depression was significantly higher in the treatment group than that in the control group(90.0%vs.74.0%,χ^(2)=4.336,P<0.05).Conclusion Qishen Yiqi dropping pill can not only improve the myocardial blood supply,but also effectively improve the psychological state of patients and relieve the depression.
作者
刘园园
张恩圆
王诚建
杨世诚
司海龙
薛媛媛
郑君毅
LIU Yuanyuan;ZHANG Enyuan;WANG Chengjian;YANG Shicheng;SI Hailong;XUE Yuanyuan;ZHENG Junyi(Department of Cardiology,Tianjin Chest Hospital,Tianjin 300222,China)
出处
《天津医药》
CAS
北大核心
2023年第5期508-512,共5页
Tianjin Medical Journal
基金
天津市医学重点学科(专科)建设项目
天津市卫生健康委员会、天津市中医药管理局中医中西医结合科研课题(2019111)。
关键词
冠心病
抑郁
经皮冠状动脉介入治疗
芪参益气滴丸
coronary disease
depression
percutaneous coronary intervention
Qishen Yiqi dropping pill
