摘要
目的研究妊娠期甲状腺功能减退症(甲减)的影响因素、危险性及妊娠结局。方法选取160例孕妇,根据是否发生甲减分为甲减组和正常组,各80例。分析孕妇妊娠期甲减的影响因素、危险性及妊娠结局。结果甲减组年龄≥30岁、妊娠次数≥2次、产次≥3次、有自然流产史、有妊娠期合并症、抗甲状腺过氧化物酶抗体(TPO-Ab)阳性、碘摄入量过低孕妇占比明显高于正常组,差异具有统计学意义(P<0.05)。Logistic回归分析显示:年龄≥30岁、妊娠次数≥2次、产次≥3次、有自然流产史、有妊娠期高血压疾病、有妊娠期糖尿病、TPO-Ab阳性及低碘摄入均是影响妊娠合并甲减的危险因素(P<0.05)。甲减组孕妇胎膜早破率11.25%、剖宫产率46.25%高于正常组的2.50%、26.25%,差异具有统计学意义(P<0.05),两组前置胎盘率、胎盘早剥率、羊水异常率及产后出血率比较,差异均无统计学意义(P>0.05)。结论妊娠期甲减的影响因素主要为年龄≥30岁、妊娠次数≥2次、产次≥3次、有自然流产史、有妊娠期高血压疾病、有妊娠期糖尿病、TPO-Ab阳性及低碘摄入。临床应在日常孕检过程中进行针对性干预,以有效降低妊娠期甲减发生率。
Objective To study the influencing factors,risk and pregnancy outcome of hypothyroidism during pregnancy.Methods 160 pregnant women were selected and divided into hypothyroidism group and normal group(80 cases each)according to whether hypothyroidism occurred.To analyze the influencing factors,risk and pregnancy outcome of hypothyroidism during pregnancy.Results The proportion of pregnant women in hypothyroidism group with age≥30 years old,number of gestation M2,birth N3,history of spontaneous abortion,complications during pregnancy,positive TPO-Ab and low iodine intake was significantly higher than that in normal group,and the difference was statistically significant(P<0.05).Logistic regression analysis showed that age ≥30 years old,number of pregnancies ≥2,number of births ≥3,history of spontaneous abortion,gestational hypertension,gestational diabetes,positive TPO-Ab and low iodine intake were all risk factors for pregnancy with hypothyroidism(P<0.05).The rates of premature rupture of membranes and cesarean section in hypothyroidism group were 11.25%and 46.25%higher than those in normal group 2.50%and 26.25%(P<0.05).There were no significant differences in the rates of placenta previa,placenta abruption,amniotic fluid abnormality and postpartum hemorrhage between the two groups(P>0.05).Conclusion The main influencing factors of hypothyroidism in pregnancy are age 230 years old,number of pregnancies≥2,number of births≥3,history of spontaneous abortion,gestational hypertension,gestational diabetes,positive TPO-Ab and low iodine intake.In order to effectively reduce the incidence of hypothyroidism during pregnancy,targeted intervention should be carried out in the course of daily pregnancy examination.
作者
郭文龙
Guo Wenlong(Department of Obstetrics and Gynecology,The Second Affiliated Hospital of Baotou Medical College,Baotou 014000,China)
出处
《实用妇科内分泌电子杂志》
2022年第34期37-40,共4页
Electronic Journal of Practical Gynecological Endocrinology
关键词
妊娠期孕妇
甲状腺功能减退症
影响因素
危险性
妊娠结局
Pregnant women during pregnancy
Hypothyroidism
Influencing factors
Danger
Pregnancy outcome
