摘要
目的:探讨前列腺汽化电切术(transurethral electroevaporation of the prostate,TUVP)治疗前列腺增生(benign prostatic hyperplasia,BPH)合并慢性前列腺炎(chronic prostatitis,CP)患者的效果及其对炎症因子、尿动力学的影响。方法:选取2020年1月—2021年1月佳木斯市中心医院收治的90例BPH合并CP患者,按照随机数表法分为两组,每组各45例。对照组采用药物治疗,观察组在药物治疗的基础上行TUVP治疗。比较两组患者国际前列腺症状量表评分(international prostate symptom score,IPSS),慢性前列腺炎症状量表评分(national institutes of health chronic prostatitis symptom index,NIH-CPSI),炎症因子[白介素-1β (interleukin-1β,IL-1β)、IL-2和肿瘤坏死因子-α (tumor necrosis factor-α,TNF-α)]水平,尿动力学指标[最大尿流率(maximum urine flow rate,QMax)、最大逼尿肌压力(maximum detrusor pressure,Pdet.max)、残余尿量(post-void residual,PVR)]和并发症发生情况。结果:治疗后,两组患者IPSS、NIH-CPSI评分均下降,且观察组低于对照组,差异有统计学意义(t=26.409、23.970,P<0.05);治疗后,两组患者血清IL-1β、IL-2和TNF-α水平下降,且观察组低于对照组,差异有统计学意义(t=14.240、17.078、17.694,P<0.05);治疗后,两组患者QMax增加,Pdet.max、PVR减少,且观察组QMax高于对照组,Pdet.max、PVR低于对照组,差异有统计学意义(t=14.169、10.533、35.491,P<0.05);观察组并发症发生率与对照组比较,差异无统计学意义(χ^(2)=2.589,P>0.108)。结论:TUVP治疗BPH合并CP患者效果确切,能缓解患者下尿路症状和前列腺炎症状,减轻其炎症反应,改善尿动力学。
Objective:To investigate the effect of transurethral electroevaporation of the prostate(TUVP)in the treatment of be⁃nign prostatic hyperplasia(BPH)combined with chronic prostatitis(CP)and its effect on inflammatory factors and urodynamics.Methods:90 patients with BPH combined with CP admitted to the hospital from January 2020 to January 2021 were selected and divided into two groups according to the random number table method,with 45 cases in each group.The control group was treated with drugs,and the observation group was treated with TUVP on the basis of drug treatment.The international prostate symptom score(IPSS),national institutes of health chronic prostatitis symptom index(NIH-CPSI),inflammatory factors(interleukin-1β[IL-1β],IL-2 and tumor necrosis factor-α[TNF-α])levels,urodynamic indices(maximum urine flow rate[QMax],maximum detru⁃sor pressure[Pdet.max],post-void residual[PVR])and complications were compared.Results:After treatment,IPSS and NIH-CPSI scores decreased in both groups and were lower in the observation group than in the control group,with statistically significant dif⁃ferences(t=26.409,23.970,P<0.05).After treatment,serum IL-1β,IL-2 and TNF-αlevels decreased in both groups,and were lower in the observation group than in the control group,with statistically significant differences(t=14.240,17.078,17.694,P<0.05).After treatment,QMax increased and Pdet.max and PVR decreased in both groups,and QMax in the observation group was higher than that in the control group,and Pdet.max and PVR were lower than that in the control group,with statistically significant differences(t=14.169,10.533,35.491,P<0.05).There was no statistically significant difference in the complication rate between the observation group and the control group(χ^(2)=2.589,P>0.108).Conclusion:TUVP is effective in treating BPH combined with CP,relieving lower urinary tract symptoms and prostatitis symptoms,reducing the inflammatory response,and improving urodynamics.
作者
张志忠
ZHANG Zhi-zhong(Department of UrologyⅡ,Jiamusi Central Hospital,Jiamusi,Heilongjiang,154002,China)
出处
《黑龙江医学》
2023年第8期925-928,共4页
Heilongjiang Medical Journal
关键词
前列腺汽化电切术
前列腺增生
慢性前列腺炎
炎症因子
尿动力学
Transurethral electrovaporization prostatectomy
Benign prostatic hyperplasia
Chronic prostatitis
Inflammatory fac⁃tors
Urodynamics
