摘要
光动力治疗(PDT)是一种有效的肿瘤微创治疗手段,可联合胆管支架、胆道外引流、化疗等全身治疗方法治疗胆管癌,主要适用于不可手术切除胆管癌的治疗和术后肿瘤残留或局部复发的辅助性治疗,可有效控制肿瘤局部进展、解除胆道梗阻、改善患者生活质量、延长生存期,具有微创、精准及可重复等优点。目前用于胆管癌PDT的临床循证医学证据有限,缺乏临床诊疗技术规范和共识。中华医学会外科学分会外科手术学组、中华医学会外科学分会胆道外科学组及中国医师协会外科医师分会胆道外科医师委员会组织相关专家,对其适应证、禁忌证、技术操作规范、疗效评价及并发症处理等进行讨论,并达成共识,旨在为PDT在胆管癌治疗中的临床应用提供参考。
Photodynamic therapy(PDT)is an effective,minimally invasive method for tumor treatment.It can be applied to the treatment of cholangiocarcinoma in combination with the implementation of biliary stent/external biliary drainage or with systemic treatments,including chemotherapy.In addition,it is a primary application in the treatment of unresectable cholangiocarcinoma as well as an adjuvant treatment of residual postoperatively or locally recurrent tumors.It can control local tumor progression effectively,relieve biliary obstruction,improve quality of life,and prolong survival,with the advantages of being minimally invasive,precise and repeatable.To date,evidence-based clinical medicine for the application of PDT to treat cholangiocarcinoma has been limited,and there has been a lack of clinical specifications and consensus regarding the technique.Based on this,Group of Operative Surgery,Branch of Surgery,Chinese Medical Association,Group of Biliary Surgery,Branch of Surgery,Chinese Medical Association and Chinese Committee of Biliary Surgeons organized experts to discuss indications,contraindications,technical protocol,evaluation of efficacy,and management of complications when using PDT to treat cholangiocarcinoma.The consensus aims to provide a reference for promoting the clinical application of PDT in the treatment of cholangiocarcinoma.
作者
中华医学会外科学分会外科手术学组
中华医学会外科学分会胆道外科学组
中国医师协会外科医师分会胆道外科医师委员会
吕毅
陈规划
全志伟
张晓刚
耿智敏
王健东
汤朝晖
尚东
Group of Operative Surgery,Branch of Surgery,Chinese Medical Association;Group of Biliary Surgery,Branch of Surgery,Chinese Medical Association;Chinese Committee of Biliary Surgeons;Lyu Yi;Chen Guihua;Quan Zhiwei(不详;Department of Hepatobiliary Surgery,the First Afiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China;Department of Hepatic Surgery,Liver Transplantation Center,the Third Affliated Hospital of Sun Yat-sen University,Guangzhou 510630,China;Department of General Surgery,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200092,China)
出处
《中华外科杂志》
CAS
CSCD
北大核心
2023年第4期265-276,共12页
Chinese Journal of Surgery
基金
国家自然科学基金(62076194)
陕西省重点研发计划(2020ZDLSF04-08,2022ZDLSF04-09)
陕西省科技厅两链融合项目(国家医学中心)(2021LL-JB-06)。
关键词
胆管肿瘤
肿瘤治疗方案
光动力治疗
专家共识
Bile duct neoplasms
Antineoplastic protocols
Photodynamic therapy
Expert consensus
