摘要
目的探讨壮族泌尿系结石患者的发病影响因素,并分析其结石成分特点。方法选取184例壮族泌尿系结石患者作为结石组,取100例壮族健康体检者作为对照组。比较两组研究对象的一般特征、血液代谢指标及24 h尿液代谢指标。采用二元Logistic回归模型分析壮族泌尿系结石患者发病的影响因素。分析结石组患者的结石成分,并比较不同结石成分的泌尿系结石患者代谢异常的发生率。结果结石组的血清肌酐、血清尿酸、尿草酸、尿尿酸、尿钙水平均高于对照组,24 h尿量及尿枸橼酸水平均低于对照组(均P<0.05)。二元Logistic回归模型分析结果显示,血清尿酸、尿尿酸、尿钙水平是壮族泌尿系结石患者发病的危险因素,而24 h尿量是其保护因素(均P<0.05)。结石组患者的结石以草酸钙结石、无水尿酸结石为主;草酸钙结石患者的高钙尿症、高草酸尿症发生率均高于其他结石成分的患者,无水尿酸结石患者的高尿酸尿症发生率均高于其他结石成分的患者(均P<0.05)。结论血清尿酸、尿尿酸、尿钙水平是壮族泌尿系结石患者发病的危险因素,而24 h尿量是其保护因素。壮族泌尿系结石患者的结石以草酸钙结石、无水尿酸结石为主,泌尿系结石的形成与机体代谢异常密切相关。
Objective To investigate the influencing factors for morbidity of Zhuang patients with urinary calculi,and to analyze characteristics of calculus compositions.Methods A total of 184 Zhuang patients with urinary calculi were selected as calculus group,and 100 Zhuang healthy check-up individuals as control group.The general features,blood metabolic indices,and 24-hour urinary metabolic indicators of the research subjects were compared between the two groups.The influencing factors for morbidity of Zhuang patients with urinary calculi were analyzed by using binary Logistic regression model.The calculus compositions were analyzed in patients of the calculus group,and the incidence rate of metabolic abnormalities were compared between the urinary calculi patients with different calculus compositions.Results The calculus group exhibited higher levels of serum creatinine,serum uric acid,urinary oxalic acid,urinary uric acid,urinary calcium,whereas lower 24-hour urinary volume and urinary citric acid level as compared with the control group(all P<0.05).The results of binary Logistic regression model analysis revealed that serum uric acid,urinary uric acid,and urinary calcium levels were the risk factors for morbidity of Zhuang patients with urinary calculi,while 24-hour urinary volume was the protective factor(all P<0.05).Calculus compositions of patients in the calculus group were mainly calcium oxalate calculus and anhydrous uric acid calculus.The incidence rates of hypercalciuria and hyperoxaluria in patients with calcium oxalate calculus were higher than those in patients with other calculus compositions,and the incidence rate of hyperuricuria in patients with anhydrous uric acid calculus was higher than that in patients with other calculus compositions(all P<0.05).Conclusion Serum uric acid,urinary uric acid and urinary calcium levels are risk factors for morbidity of Zhuang patients with urinary calculi,whereas 24-hour urinary volume is its protective factor.Calculi of Zhuang patients with urinary calculi are mainly calcium oxalate calculus and anhydrous uric acid calculus,and the formation of urinary calculi is closely associated with the body metabolic abnormalities.
作者
覃天资
梁洁
吴计超
黄群
龙毅
孟冬冬
甘福
崖文童
QIN Tianzi;LIANG Jie;WU Jichao;HUANG Qun;LONG Yi;MENG Dongdong;GAN Fu;YA Wentong(School of Clinical Medicine,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China;Department of Urinary Surgery,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,China)
出处
《广西医学》
CAS
2023年第6期656-660,共5页
Guangxi Medical Journal
基金
广西高校中青年教师科研基础能力提升项目(2020KY13014)
右江民族医学院附属医院高层次人才科研项目(Y202011717)。
关键词
泌尿系结石
影响因素
结石成分
代谢指标
壮族
Urinary calculi
Influencing factors
Calculus composition
Metabolic indices
Zhuang Nationality
