摘要
目的挖掘分析中医治疗原发性干燥综合征(pSS)文献,总结pSS的证候特点和遣方用药规律。方法在中国知网、万方数据库中检索2011年1月至2021年12月有关中医治疗pSS的文献,采用Excel依次统计中医证候要素、舌脉、方药等,采用SPSS 25.0、SPSS Modeler、Cytoscape软件分别进行聚类分析、关联分析、复杂网络分析。结果纳入文献145篇,证型以气阴两虚为主;舌脉以细脉、红舌、数脉、剥苔为主;除自拟方外,常用益胃汤;涉及197味中药,以麦冬、甘草、生地黄居多,药味以甘、苦、辛为主,药性以寒、平为主,多归肺、肝、胃三经;中药系统聚类分析得到7组核心药组;关联分析得到14组关联规则;复杂网络分析得到核心药物组合为麦冬、生地黄、沙参、甘草。结论pSS证型以气阴两虚为本,淤、毒、痰湿为标,治以“补益肝肾,滋肺益胃”为本,辅以活血化瘀药、清热凉血药、理气药等。
Objective To excavate and analyze the literature on the treatment of primary Sjogren’s syndrome(pSS)by traditional Chinese medicine,and to summarize the syndrome characteristics and medication rules of pSS.Methods The literature related to traditional Chinese medicine treatment of pSS from January 2011 to December 2021 was retrieved from CNKI and Wanfang data,and the traditional Chinese medicine syndrome elements,tongue and pulse,prescriptions,and so on were counted successively by Excel.SPSS 25.0,SPSS Modeler and Cytoscape were used for cluster analysis,association analysis,and complex network analysis respectively.Results A total of 145 literatures were included,and the syndrome types were mainly Qi and Yin deficiency.The tongue pulse was mainly fine pulse,red tongue,number pulse,and moss stripping.In addition to the self-designed formula,Yiwei decoction was often used;there were 197 kinds of traditional Chinese medicines involved,mainly ophiopogon ophiopogon,licorice and radix rehmanniae.The medicinal tastes were mainly sweet,bitter and pungent,while the medicinal properties were mainly cold and flat,which were mainly attributed to the three classics of lung,liver,and stomach.Seven core drug groups were obtained by systematic cluster analysis.A total of 14 groups of association rules were obtained by association analysis.Complex network analysis showed that the core drug combinations were ophiopogon ophiopogon,Radix rehmanniae,Radix ginseng and licorice.Conclusion pSS syndrome type is based on“Qi and Yin deficiency,stasis,toxicity,phlegm,and dampness as the standard”,and the treatment is based on“tonifying liver and kidney,tonifying lung and tonifying stomach”,supplemented by activating blood circulation and removing blood stasis,clearing heat and cooling blood,regulating qi,and so on.
作者
位娜鑫
孙红艳
WEI Naxin;SUN Hongyan(College of Traditional Chinese Medicine,Xinjiang Medical University Institute of Traditiaonal Chinese Medicine,Xinjiang Uygur Autonomous Region,Urumqi830017,China)
出处
《中国医药导报》
CAS
2023年第11期9-13,共5页
China Medical Herald
基金
国家自然科学基金地区科学基金项目(81860835)
新疆维吾尔自治区自然科学基金面上项目(2018D01C173)。
关键词
原发性干燥综合征
中医证候
方药
用药规律
数据挖掘
Primary Sjogren’s syndrome
Traditional Chinese medicine syndrome
Prescription
Medication law
Data mining
