摘要
单纯疱疹病毒Ⅰ型(HSV-1)感染引起的单纯疱疹病毒性角膜炎(HSK)是全球性的致盲性眼病。病毒在眼表发生原发感染后,转运并终生潜伏在三叉神经节内,反复复发引起角膜病变。在对HSV潜伏机制方面的研究过程中,人们逐渐认识到病毒自身和宿主反应两方面共同调控了病毒的潜伏过程。近年来,嗜神经病毒的侵袭、免疫、潜伏复发等各方面的分子机制研究取得大量研究成果,为HSK的防治提供了新思路。本文将主要对HSV-1角膜初发感染后在三叉神经节内潜伏分子机制方面的研究进展进行介绍,并对目前HSK的基础研究和临床治疗存在的问题进行探讨。
Herpes simplex keratitis(HSK),caused by the infection of herpes simplex virus typeⅠ(HSV-1)in cornea,is a global blinding corneal disease.After the primary infection in ocular surface,HSV-1 is transported into trigeminal ganglion and establishes the life-lasting latency,and it results in recurrent keratopathy.In the process of studying the latent mechanism of HSV,it has been gradually recognized that both the virus itself and the host response regulate the latent process of HSV.In recent years,a large number of research results have been obtained on the molecular mechanisms of invasion,immunity,latency and recurrence of neurotropic viruses,which provide new ideas for the prevention and treatment of HSK.In the present review,the recent progress of HSV latency mechanism in trigeminal ganglion after the primary infection in corneal surface was introduced,and the unsolved basic and clinical problems in HSK were discussed.
作者
董亚慧
赵格
周庆军
Ya-Hui Dong;Ge Zhao;Qing-Jun Zhou(Jinan Mingshui Eye Hospital,Jinan 250200,Shandong Province,China;China Animal Health and Epidemiology Center,Qingdao 266032,Shandong Province,China;Shandong First Medical University&Shandong Academy of Medical Sciences,Shandong Eye Institute,Qingdao Eye Hospital of Shandong First Medical University,State Key Laboratory Cultivation Base,Shandong Provincial Key Laboratory of Ophthalmology,Qingdao 266071,Shandong Province,China)
出处
《国际眼科杂志》
CAS
北大核心
2023年第5期787-790,共4页
International Eye Science
关键词
单纯疱疹病毒
潜伏
分子机制
三叉神经节
herpes simplex virus
latency
molecular mechanisms
trigeminal ganglion
