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纳米混悬制剂在兽药中的研究进展

Progress in research on nanosuspension preparations in veterinary medicine
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摘要 部分兽药原料药由于水溶性较差或渗透性较低,导致生物利用度低,不能发挥良好的疗效。将药物制成纳米混悬制剂,能够减小药物粒度,改善药物溶解度,增加药物溶出度,并改变药物在生物体内的药代动力学特征,有效提高生物利用度。另外,纳米混悬制剂具备制造方法简单、条件温和等优势,满足理想的兽药开发条件。本文就纳米混悬制剂的制备方法,及其在兽药应用领域给药途径进行了综述,为纳米混悬制剂在兽药领域的研制提供参考及借鉴。 Some veterinary drugs have poor solubility in water and low bioavailability,and cannot exert good curative effects.Nano-suspension formulations can reduce the particle size of the drugs,improve their solubility,increase their dissolution rate,and enhance their bioavailability.Nano-suspension has the advantages of easy manufacturing and requires moderate conditions.This article reviews the methods of nano-suspension preparations and their route of administration in application in the field of veterinary medicine,and provides reference and discussion for the development of nano-suspension preparations in the field of veterinary medicine.
作者 毛倩倩 王丽 周祥莹 赵志宏 路庭欢 张岩 MAO Qianqian;WANG Li;ZHOU Xiangying;ZHAO Zhihong;LU Tinghuan;ZHANG Yan(Qingdao Vland Biotech Co.,Ltd.,/Qingdao Continent Animal Pharmaceutical Co.,Ltd.,Qingdao 266109,China)
出处 《畜牧与兽医》 CAS 北大核心 2023年第4期139-143,共5页 Animal Husbandry & Veterinary Medicine
关键词 纳米混悬制剂 制备方法 给药途径 兽药 nano-suspensions preparation technology drug administration route veterinary medicine
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