期刊文献+

利用溶液色差值与吸光度的相关性建立头孢西丁钠溶液颜色的仪器测定方法

Establishment of an instrumental method for determination of the color of cefoxitin sodium solution by using the correlation between solution color difference and absorbance
下载PDF
导出
摘要 目的建立一种客观量化的注射用头孢西丁钠溶液颜色的仪器测定方法。方法借助色差计考察色差值与溶液吸光度的相关性,选择相关性最强的波长作为检测波长,并在该波长下对注射用头孢西丁钠溶液颜色的药典标准进行限度转换。结果建立了在420 nm波长处测定注射用头孢西丁钠吸光度的溶液颜色仪器测定方法,吸光度限度规定为不得过0.17。结论该方法能够准确量化测定并表述注射用头孢西丁钠的溶液颜色,为更好的研究与控制药品质量提供了数据支持,也为其他药品的溶液颜色检查从粗略的目视法转变为精准量化的仪器法提供了参考。 Objective To establish an objective quantified method for color determination of cefoxitin sodium solution for injection.Methods The correlation between the color difference value and the absorbance of the solution was investigated by the chromatic meter,and the wavelength with the strongest correlation was selected as the detection wavelength,and the color limit of cefoxitin sodium solution for injection was determined by investigating the absorbance value of the corresponding standard colorimetric solution at the selected detection wavelength.Results A method for the determination of the color of cefoxitin sodium solution for injection was established.The absorbance of the solution was determined at 450 nm wavelength and should not exceed 0.17.Conclusion This method can accurately quantify the solution color of cefoxitin sodium for injection,which provides data support for better research and control of drug quality,and also provides a reference for the transformation of solution color inspection of other drugs from rough visual methods to precise quantitative instrument methods.
作者 刘海涛 侯金凤 寇晋萍 刘琦 齐麟 Liu Hai-tao;Hou Jin-feng;Kou Jin-ping;Liu Qi;Qi Lin(Beijing Institute for Drug Control,NMPA Key Laboratory for Research and Evaluation of Generic Drugs,Beijing Key Laboratory of Analysis and Evaluation on Chinese Medicine,Beijing 102206)
出处 《中国抗生素杂志》 CAS CSCD 北大核心 2023年第3期338-342,共5页 Chinese Journal of Antibiotics
关键词 注射用头孢西丁钠 色差计 溶液颜色检查法 相关性 限度转换 精准量化 Cefoxitin sodium for injection Chromatic meter Solution color test Correlation Limit conversion Precise quantization
  • 相关文献

参考文献3

二级参考文献11

  • 1国家药典委员会编,国家药品标准工作手册.第3版.1999:103,164.
  • 2CNAS-CL01:2006.检测和校准实验室能力认可准则[S].
  • 3《中国药典》2005年(二部).北京:化学工业出版社,2005:216.
  • 4世界卫生组织.药品质量控制实验室管理规范[S].2010.
  • 5国家质量监督检验检疫总局.标准物质常用术语和定义[S].中华人民共和国国家计量技术规范JJF1005-2005,2005.
  • 6中国合格评定国家认可委员会.量值溯源要求[S].CNAS-CL06,2011.
  • 7全国标准样品技术委员会.标准样品定值的一般原则和统计方法[S].GB/T15000.3-2008,2008.
  • 8中国合格评定国家认可委员会.标准物质/标准样品生产者能力认可准则[S].CNASCL04.2010.
  • 9国家质量监督检验检疫总局.液相色谱仪[S].中华人民共和国国家计量检定规程JJG705-2002,2002.
  • 10国家质量监督检验检疫总局.电子天平[S].中华人民共和国国家计量检定规程JJG1036-2008,2008.

共引文献16

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部