摘要
本文以邻硝基苯甲醛、对氨基苯乙酮为原料,设计了一种在无金属催化体系下合成(4-氨基苯)(苯并噻吩-2-基)甲酮的新方法,目标化合物结构经1H NMR,13 C NMR表征。对无金属催化环化反应进行反应条件探索,发现当羟醛缩合的产物丙烯酮与S 8以1∶5物料比混合,在DIPEA介导下,80℃,DMSO中反应16 h,可较高产率(68%)得到目标化合物。
In this paper,a new method for the synthesis of(4-aminobenzene)(benzothiophen-2-yl)methanone with o-nitrobenzaldehyde and p-aminoacetophenone as raw materials was designed in a metal-free catalytic system.Its structure was characterized by 1 H NMR and 13 C NMR.The reaction conditions of metal-free catalytic cyclization were investigated.The reaction conditions of metal-free catalytic cyclization were investigated,and it was found that when the product of hydroxyl aldehyde condensation was mixed with elemental sulfur at a material ratio of 1∶5,and DIPEA was used as catalyst,the reaction in DMSO for 16 h at 80℃,the good yield(68%)of the target compound could be obtained.
作者
肖彩琴
XIAO Cai-qin(Chemical Engineering Institute,Jiuquan Vocational and Technical College,Jiuquan 735000,China)
出处
《兰州石化职业技术学院学报》
2022年第4期1-5,共5页
Journal of Lanzhou Petrochemical Polytechnic
基金
2020年甘肃省高等学校创新能力提升项目(2020B-379)。
关键词
查尔酮
无机硫
环化
苯并噻吩
chalcone ketones
Inorganic sulfur
cyclization
benzothiophen-2-yl
