摘要
类风湿关节炎(RA)是一种以侵袭性滑膜炎为病理特征的慢性自身免疫性疾病,其发病机制尚未完全阐明。目前认为是遗传易感性个体,在环境因素的影响下瓜氨酸化自身抗原,刺激产生抗瓜氨酸化抗体,后者以二次打击模式造成关节及附属器的损伤。肠道菌群就是重要的环境因素之一,其紊乱破坏肠黏膜屏障,引发肠黏膜下炎症,活化的炎症细胞和促炎细胞因子以及菌群代谢产物能够通过肠黏膜进入血运循环,以肠-关节轴形式参与到RA发病机制中。近年研究发现,口服益生菌可通过重建肠道菌群平衡,调节代谢和免疫治疗RA。
Rheumatoid arthritis(RA)is a chronic autoimmune disease characterized by invasive synovitis.The pathogenesis has not been fully elucidated.It is currently believed that genetically susceptible individuals,under the influence of environmental factors,may have autoantigens citrullinated and be stimulated to produce anti-citrullinated antibodies which can cause joint damage in a“two-hit”model.Intestinal microbiota is one of the important environmental factors whose disorder can damage the intestinal mucosal barrier and cause intestinal submucosal inflammation.Activated inflammatory cells,proinflammatory cytokines,and microbial metabolites can enter the blood circulation through intestinal mucosa and participate in the pathogenesis of RA in the form of gut-joint axis.Recent studies have found that oral probiotics can be used to treat RA by reestablishing the balance of gut microbiota,regulating metabolism and immunity.
作者
李绘林
李鸿斌
LI Hui-lin;LI Hong-bin(Department of Rheumatology and Immunology,Affiliated Hospital of Inner Mongolia Medical University/Inner Mongolia Key Laboratory of Pathogenesis and Immunodiagnosis of Rheumatic Diseases/Key Laboratory of Autoimmunity and Rheumatology,Inner Mongolia Medical University,Hohhot 010050,China)
出处
《中华临床免疫和变态反应杂志》
CAS
2023年第1期45-49,共5页
Chinese Journal of Allergy & Clinical Immunology
基金
国家自然科学基金(81660276)
卫生健康科技计划项目A类(202201270)
十四五自治区重点研发和成果转化项目(2022YFSH0093)。
