摘要
目的研究子痫前期(PE)患者孕期血栓调节蛋白(TM)水平与产后血管内皮功能的相关性。方法选取2018年2月至2021年2月江苏省淮安市第一人民医院PE患者108例。所有患者均检测孕期TM水平,并根据产后6周内皮依赖性血流介导的血流扩张值将其分为血管内皮功能异常组和血管内皮功能正常组。分析产后血管内皮功能异常的影响因素,受试者操作特征曲线评估TM对血管内皮功能的预测价值。结果108例PE患者血管内皮功能异常47例。血管内皮功能异常组收缩压(SBP)、舒张压(DBP)、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、TM高于血管内皮功能正常组(P<0.05)。PE患者孕期TM水平与血管内皮功能呈负相关(r=-0.416,P<0.05)。SBP、DBP、hsCRP、TM为血管内皮功能的影响因素(OR=3.592、2.641、4.675、3.872,P<0.05)。孕期TM预测产后血管内皮功能异常的cut-off值为44.87μg/L,曲线下面积为0.865,灵敏度为85.11%,特异度为83.61%。结论PE患者孕期TM水平与产后血管内皮功能具有密切关联性,可为临床诊治提供合理依据。
Objective To study the correlation between the level of thrombomodulin(TM)during pregnancy and postpartum vascular endothelial function in patients with preeclampsia(PE).Methods A total of 108 PE patients in Huai’an First People’s Hospital,Jiangsu Province from February 2018 to February 2021 were selected.All patients were tested for TM levels during pregnancy,according to endothelial dependent flow mediated dilation value at six weeks postpartum,they were divided into abnormal vascular endothelial function group and normal vascular endothelial function group.The influencing factors of postpartum vascular endothelial dysfunction were analyzed,and the predictive value of TM on vascular endothelial function was evaluated by receiver operating characteristic curve.Results Systolic blood pressure(SBP),diastolic blood pressure(DBP),homocysteine(Hcy),hypersensitive C-reactive protein(hs-CRP),and TM in abnormal vascular endothelial function group were higher than those in normal vascular endothelial function group(P<0.05).TM level during pregnancy was negatively correlated with vascular endothelial function in PE patients(r=-0.416,P<0.05).SBP,DBP,hs-CRP,and TM were the influencing factors of vascular endothelial function(OR=3.592,2.641,4.675,3.872,P<0.05).The cut-off value of TM during pregnancy for predicting postpartum vascular endothelial dysfunction was 44.87μg/L,area under the curve was 0.865,sensitivity was 85.11%,and specificity was 83.61%.Conclusion The TM level of PE patients during pregnancy is closely related to postpartum vascular endothelial function,which can provide reasonable basis for clinical diagnosis and treatment.
作者
杨亚文
周巧娟
赵爱
邵雯
YANG Yawen;ZHOU Qiaojuan;ZHAO Ai;SHAO Wen(Department of Obstetrics,Huai’an First People’s Hospital,Jiangsu Province,Huai’an 223300,China;Department of Ultrasonography,Huai’an First People’s Hospital,Jiangsu Province,Huai’an 223300,China)
出处
《中国医药导报》
CAS
2023年第12期111-114,共4页
China Medical Herald
基金
江苏省科技计划项目(面上基金项目)(BK20201122)。
关键词
子痫前期
血栓调节蛋白
产后血管内皮功能
相关性
Preeclampsia
Thrombomodulin
Postpartum vascular endothelial function
Correlation
