摘要
目的:研究丹红注射液联合常规西药治疗对冠心病经皮冠状动脉介入治疗(PCI)术后再发心绞痛的影响。方法:选取2017年1月—2020年1月北京市宣武中医医院收治的90例冠心病PCI术后再发心绞痛患者。根据随机数表法将其分为对照组及研究组,各45例。两组均开展常规药物治疗以控制血糖、血脂、血压。对照组采取常规西药治疗,研究组在对照组基础上给予丹红注射液治疗。比较两组临床疗效,治疗前、治疗2周后心绞痛发作情况、血管内皮功能、炎症因子。结果:研究组总有效率为88.89%,高于对照组的71.11%,差异有统计学意义(P<0.05)。治疗2周后,研究组心绞痛发作频率低于对照组,持续时间短于对照组,差异有统计学意义(P<0.05)。治疗2周后,研究组血管内皮依赖性舒张功能(FMD)、一氧化氮(NO)均高于对照组,内皮素1(ET-1)低于对照组,差异有统计学意义(P<0.05)。治疗2周后,研究组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)水平均低于对照组,差异有统计学意义(P<0.05)。结论:冠心病PCI术后再发心绞痛采取丹红注射液联合常规西药治疗,能够降低炎症因子水平,改善血管内皮功能,减少心绞痛发作,整体治疗效果好。
Objective:To study the effect of Danhong Injection combined with conventional western medicine on recurrent angina pectoris after percutaneous coronary intervention(PCI)operation for coronary heart disease.Method:A total of 90 patients with recurrent angina pectoris after PCI operation for coronary heart disease in Beijing Xuanwu Traditional Chinese Medicine Hospital from January 2017 to January 2020 were selected.According to the random number table method,they were divided into control group and study group,45 cases in each group.Both groups were given routine drug therapy to control blood glucose,blood lipid and blood pressure.The control group was treated with conventional western medicine,and the study group was treated with Danhong Injection on the basis of the control group.The clinical efficacy,angina onset condition,vascular endothelial function and inflammatory factors before treatment and after 2 weeks of treatment were compared between the two groups.Result:The total effective rate of the study group was 88.89%,which was higher than that of the control group(71.11%),and the difference was statistically significant(P<0.05).After 2 weeks of treatment,the frequency of angina pectoris in the study group was lower than that in the control group,and the duration was shorter than that in the control group,and the differences were statistically significant(P<0.05).After 2 weeks of treatment,the vascular endothelium-dependent diastolic function(FMD)and nitric oxide(NO)in the study group were higher than those in the control group,and the endothelin-1(ET-1)was lower than that in the control group,and the differences were statistically significant(P<0.05).After 2 weeks of treatment,the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Danhong Injection combined with conventional western medicine treatment for recurrent angina pectoris after PCI operation for coronary heart disease can reduce the level of inflammatory factors,improve the vascular endothelial function,reduce the onset of angina pectoris,the overall treatment effect is good.
作者
张杰群
ZHANG Jiequn(Beijing Xuanwu Traditional Chinese Medicine Hospital,Beijing 100050,China)
出处
《中外医学研究》
2023年第10期60-63,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
丹红注射液
常规西药
冠心病
经皮冠状动脉介入治疗
心绞痛
Danhong Injection
Conventional western medicine
Coronary heart disease
Percutaneous coronary intervention
Angina pectoris
