摘要
目的 探讨红细胞分布宽度变异系数(RDW-CV)及标准差(RDW-SD)在结直肠癌(CRC)转移诊断中的临床应用价值。方法 以91例住院CRC患者为研究对象,依据肿瘤是否转移分为2组:未转移组61例和转移组30例,分析两组患者实验室指标包括中性粒细胞计数、淋巴细胞计数、血小板计数、癌胚抗原、血浆凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原、凝血酶时间以及RDW-CV和RDW-SD等。两组均数比较采用t检验,同时运用Pearson相关分析RDW-CV和RDW-SD与中性粒细胞计数、淋巴细胞计数、中性粒细胞计数-淋巴细胞计数比值(NLR)和癌胚抗原的相关系数,以受试者工作特征曲线(ROC)评估RDW-CV、RDW-SD、癌胚抗原及其联合诊断在评估CRC转移的曲线下面积(AUC)。结果 相较于未转移组,转移组RDW-CV和RDW-SD值升高(P<0.05)。RDW-CV和RDW-SD水平与癌胚抗原含量均呈正相关。与癌胚抗原诊断CRC转移的AUC相比较,RDW-CV或RDW-SD联合癌胚抗原的AUC增高(P<0.05)。结论 RDW-CV和RDW-SD具有鉴别诊断CRC转移的潜在临床应用价值。
Objective To investigate the clinical value of coefficient of variation(RDW-CV)and standard deviation(RDW-SD)of erythrocyte distribution width in the diagnosis of colorectal cancer(CRC)metastasis.Methods 91 CRC inpatients were selected as the research subjects.According to whether the tumor was metastatic,they were divided into two groups:61 cases in the non-metastatic group and 30 cases in the metastasis group.The laboratory indicators of the two groups of patients included:neutrophils count,lymphocyte count,platelet count,carcinoembryonic antigen,plasma prothrombin time,activated partial thromboplastin time,fibrinogen,thrombin time,RDW-CV and RDW-SD and other indicators.The t test was used to compare the means of the two groups,and the pearson correlation was used to analyze the relationship between RDW-CV and RDW-SD with neutrophil count,lymphocyte count,neutrophil count-lymphocyte count ratio(NLR)and carcinoembryonic antigen.Correlation coefficient,receiver operating characteristic curve(ROC)to assess the area under the curve(AUC)of RDW-CV,RDW-SD,carcinoembryonic antigen and their combined diagnosis in assessing CRC metastasis.Results Compared with non-metastatic patients,the RDW-CV and RDW-SD values of metastatic patients were higher(both P<0.05).Both RDW-CV and RDW-SD levels were positively correlated with carcinoembryonic antigen content.Compared with the AUC of carcinoembryonic antigen in diagnosis of CRC metastasis,the AUC of RDW-CV or RDW-SD combined with carcinoembryonic antigen was higher.Conclusion RDW-CV and RDW-SD have potential clinical application value in differential diagnosis of CRC metastasis.
作者
汪硕敏
朱勇
夏云红
Wang Shuomin;Zhu Yong;Xia Yunhong(Dept of Oncology,The First Affiliated Hospital of Anhui Medical University,Hefei 230012;Dept of Oncology,Anhui Public Health Clinical Center,Hefei 230012;Dept of General Surgery,Anhui Public Health Clinical Center,Hefei 230012)
出处
《安徽医科大学学报》
CAS
北大核心
2023年第4期698-701,共4页
Acta Universitatis Medicinalis Anhui
基金
安徽省自然科学基金(编号:2018085MH289)
安徽医科大学基础与临床合作研究提升计划项目(编号:2019xkjT029)。
关键词
结直肠癌
转移
红细胞分布宽度变异系数
红细胞分布宽度标准差
colorectal cancer
metastasis
coefficient of variation of erythrocyte distribution width
standard deviation of erythrocyte distribution width
