摘要
目的研究核桃青皮小分子酸性成分。方法核桃青皮95%乙醇提取物采用硅胶柱、Sephadex LH-20柱、ODS柱、半制备HPLC进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到14个化合物,分别鉴定为β-羟丙基香草酮(1)、白藜芦醇(2)、4-O-咖啡酰基奎宁酸甲酯(3)、对甲酚(4)、莽草酸(5)、柠檬酸(6)、新野樱苷(7)、juglanoside B(8)、没食子酸乙酯(9)、香草酸(10)、山柰酚-3-O-β-D-吡喃葡萄糖苷(11)、黄杞苷(12)、对苯二酚(13)、表二氢菜豆酸(14)。结论化合物1~7为首次从该植物中分离得到。
AIM To study the small molecule acidic constituents from walnut green husks.METHODS The 95%ethanol from walnut green husks was isolated and purified by silica gel column chromatography,Sephadex LH-20 column chromatography,ODS column chromatography and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Fourteen compounds were isolated and identified asβ-hydroxypropiovanillone(1),resveratrol(2),4-O-caffeoylquinic acid methyl ester(3),p-cresol(4),shikimic acid(5),citric acid(6),neosakuranin(7),juglanoside B(8),ethyl gallate(9),vanillic acid(10),kaempferol-3-O-β-D-glucopyranoside(11),engeletin(12),1,4-dihydroxybenzene(13),epi-dihydro phaseic acid(14).CONCLUSION Compounds 1-7 are first isolated from this plant.
作者
周媛媛
张雪柔
孙朝
王思琪
王萍
方振兴
ZHOU Yuan-yuan;ZHANG Xue-rou;SUN Zhao;WANG Si-qi;WANG Ping;FANG Zhen-xing(Ministry of Education Key Laboratory for Basic and Application Research of Beiyao,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang Provincial Academy of Traditional Chinese Medicine,Harbin 150036,China;Institute of Nature and Ecology,Heilongjiang Academy of Sciences,Harbin 150040,China)
出处
《中成药》
CAS
CSCD
北大核心
2023年第5期1528-1531,共4页
Chinese Traditional Patent Medicine
基金
国家自然科学基金项目(81202890)
中国博士后特别资助项目(2014T70374)
中国博士后面上资助项目(一等)(2013M530164)
黑龙江省自然科学基金项目(LH2019H048)
黑龙江省博士后科研启动金资助项目(LBH-Q16207)
黑龙江省“头雁”团队支持项目(黑龙江省头雁行动领导小组文件[2019]5号)。
关键词
核桃青皮
小分子酸性成分
分离鉴定
walnut green husks
small molecule acidic constituents
isolation and identification
