摘要
Prolactin(PRL)is a polypeptide hormone that is mainly synthesized and secreted by the lactotroph cells of the pituitary.There are two main isoforms of PRL:23-kDa PRL(named full-l ength PRL)and vasoinhibins(including 5.6–18 kDa fragments).Both act as circulating hormones and cytokines to stimulate or inhibit vascular formation at different stages and neovascularization,including endothelial cell proliferation and migration,protease production,and apoptosis.However,their effects on vascular function and cardiovascular diseases are different or even contrary.In addition to the structure,secretion regulation,and signal transduction of PRL/vasoinhibins,this review focuses on the pathological mechanism and clinical significance of PRL/vasoinhibins in cardiovascular diseases.
基金
National Natural Science Foundation of China,Grant/Award Number:81700045,81870042 and 81900050
Natural Science Foundation of Shanghai,Grant/Award Number:22ZR1452400
Shanghai Municipal Commission of Health,Grant/Award Number:20204Y0384
Shanghai Pulmonary Hospital,Grant/Award Number:fk18003 and fkyq1605。
