摘要
目的研究尼卡地平治疗子痫前期患者的临床效果。方法60例子痫前期患者,随机分为联合组与单药组,各30例。单药组采用硫酸镁治疗,联合组在单药组基础上联合尼卡地平治疗。对比两组治疗前后血压水平及尿蛋白含量、不良妊娠结局及产后并发症发生情况。结果治疗后,两组收缩压(SBP)、舒张压(DBP)水平均低于本组治疗前,且联合组SBP(127.47±7.29)mm Hg(1 mm Hg=0.133 kPa)、DBP(78.82±7.04)mm Hg低于单药组的(142.16±8.51)、(89.18±7.21)mm Hg,差异均有统计学意义(P<0.05)。治疗后,两组尿蛋白含量均低于本组治疗前,且联合组尿蛋白含量(1.34±0.18)g/24 h低于单药组的(1.57±0.21)g/24 h,差异均有统计学意义(P<0.05)。联合组不良妊娠结局发生率10.00%低于单药组的36.67%,差异有统计学意义(P<0.05)。两组均未发生产后并发症。结论尼卡地平在子痫前期患者治疗中的效果较好,可控制患者血压,有利于改善妊娠结局,产后血压更容易控制,降低并发症发生率。
Objective To study the clinical effect of nicardipine in patients with preeclampsia.Methods A total of 60 patients with preeclampsia were randomly divided into combination group and monotherapy group,with 30 patients in each group.The monotherapy group was treated with magnesium sulfate,and the combination group was treated with nicardipine on the basis of monotherapy group.The blood pressure and urinary protein content before and after treatment,occurrence of adverse pregnancy outcomes and postpartum complications were compared between the two groups.Results After treatment,the systolic blood pressure(SBP)and diastolic blood pressure(DBP)levels in both groups were lower than those before treatment in this group;SBP of(127.47±7.29)mm Hg(1 mm Hg=0.133 kPa)and DBP of(78.82±7.04)mm Hg in combination group were lower than those of(142.16±8.51)and(89.18±7.21)mm Hg in monotherapy group.The differences were statistically significant(P<0.05).After treatment,the urinary protein content in the two groups was lower than that before treatment in this group,and the urinary protein content of(1.34±0.18)g/24 h in combination group was lower than that of(1.57±0.21)g/24 h in monotherapy group.The differences were statistically significant(P<0.05).The incidence of adverse pregnancy outcome in combination group was 10.00%,which was lower than that of 36.67%in monotherapy group,and the difference was statistically significant(P<0.05).No postpartum complications occurred in both groups.Conclusion Nicardipine has a good effect in the treatment of preeclampsia patients.It can control the blood pressure of patients,which is conducive to improving pregnancy outcomes,easier control of postpartum blood pressure,and a lower incidence of complications.
作者
李梦霞
张晓静
LI Meng-xia;ZHANG Xiao-jing(Obstetrics Department,Chengyang District People's Hospital,Qingdao 266109,China)
出处
《中国实用医药》
2023年第8期129-131,共3页
China Practical Medicine
关键词
尼卡地平
子痫前期
硫酸镁注射液
妊娠结局
Nicardipine
Preeclampsia
Magnesium sulfate injection
Maternal and infant outcomes
