摘要
目的探究发作间期的前庭性偏头痛(VM)患者与良性阵发性位置性眩晕(BPPV)患者的静息态功能磁共振成像(rs-fMRI)特点及差异,进一步探索VM的发病机制。方法搜集2018年3月至2021年9月青岛大学附属医院崂山院区收治的三组VM患者(21例)、BPPV患者(19名),应用GE 3.0 T磁共振对所有受试者行脑部rs-fMRI扫描,对图像进行静息态处理,利用SPM12进行方差分析,采用Bonferroni多重比较的统计学方法得到局部一致性(ReHo)、低频振幅(ALFF)有差异的脑区,其中对ALFF进行GRF校正。结果VM患者与BPPV患者的左侧海马ALFF值均增高,BPPV患者更显著;VM患者的右侧额中叶ReHo值升高,BPPV患者的右侧额中叶ReHo值降低。结论VM患者与BPPV患者的rs-fMRI数据分析存在差异,具体表现在左侧海马、右侧额中叶区域。一定程度上解释了VM的发病机制。
Objective To explore the characteristics and differences of resting fMRI between patients with interictal vestibular migraine(VM)and benign paroxysmal positional vertigo(BPPV),and to further explore the pathogenesis of vestibular migraine.Methods Three groups of VM patients(21 cases),BPPV patients(20 cases)and normal subjects(19 cases)treated in Laoshan Hospital of the Affiliated Hospital of Qingdao University from March 2018 to September 2021 were collected and applied with GE 3.0 T MRI performed brain rs-fMRI scanning on all subjects,and the images were processed in a resting state.SPM 12 was used for analysis of variance.Bonferroni’s multiple comparison statistical method was used to obtain brain regions with differences in local consistency(ReHo)and low-frequency amplitude(ALFF),in which ALFF was corrected by GRF.Results The Alff value of left hippocampus in VM patients and BPPV patients increased,especially in BPPV patients;The ReHo value of the right middle frontal lobe increased in patients with VM and decreased in patients with BPPV.Conclusion There are differences in rs-fMRI data analysis between VM patients and BPPV patients,which are manifested in the left hippocampus and the right middle frontal lobe.To some extent,it explains the pathogenesis of VM.
作者
张宏泽
谭巧文
丛文斌
田宇轩
宋玉强
ZHANG Hongze;TAN Qiaowen;CONG Wenbin(The Affiliated Hospital of Qingdao University,Qingdao,Shandong Province 266100,P.R.China)
出处
《临床放射学杂志》
北大核心
2023年第2期186-189,共4页
Journal of Clinical Radiology
基金
吴阶平医学基金会临床科研专项资助基金项目(编号:QYFYWZLL26803)。
关键词
前庭性偏头痛
良性阵发性位置性眩晕
静息态功能磁共振成像
低频振幅
局部一致性
Vestibular migraine
Benign paroxysmal positional vertigo
Resting-state functional magnetic resonance imaging
Low frequency amplitude
Regional homogeneity
