摘要
肝脏疾病是当今世界上严重威胁人类健康的一大类疾病,包括各种原因导致的肝炎如脂肪性、酒精性、病毒性和自身免疫性肝炎、肝纤维化和肝癌。白细胞介素-1(interleukin-1,IL-1)家族成员参与了大多数急性和慢性肝脏疾病炎症的发生,在肝脏疾病的进展中扮演着十分关键的作用。现将围绕白细胞介素-1家族细胞因子与肝脏疾病关系的研究进展进行概述,讨论IL-1家族细胞因子在各种肝脏疾病发生发展以及相关免疫应答过程中的关键作用,并展望IL-1家族成员在药物研发和临床治疗方面的应用前景。
Liver disease is a serious threat to human health in the world,including hepatitis caused by various causes(fatty,alcoholic,viral and autoimmune hepatitis),liver fibrosis and liver cancer.Interleukin-1(IL-1)family members are involved in the inflammation of most acute and chronic liver diseases and play a key role in the progression of liver diseases.This paper reviews the research progress on the relationship between interleukin-1 family cytokines and liver diseases,discusses the key roles of IL-1 family cytokines in the occurrence and development of various liver diseases and related immune responses,and looks forward to the application prospect of IL-1 family members in drug development and clinical treatment.
作者
怀千
王华
HUAI Qian;WANG Hua(Dept of Oncology,the First Affiliated Hospital of Anhui Medical University,Hefei 230032,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2023年第5期828-832,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 81770588)
安徽高校协同创新项目(No GXXT-2021-066)。
