摘要
The conceptually designed imidodiphosphorimidates(IDPis)have emerged as one of the most potent classes of chiral acid catalysts.They are characterized by enzyme-like,highly confined active site and high acidity,which underlie their wide-reaching applications as Bronsted acid catalysts and as precatalysts for silylium Lewis acids.Many carbon-carbon and carbon-heteroatom bond formation reactions that were deemed intractable could now be attained with spectacular reactivity and selectivity.Substrates that are small,unbiased and/or possess insufficient reactivity such as simple alkenes could now be engaged.The high structural confinement is particularly invaluable to control stereo-and chemoselectivity.The well-defined steric environment offers unique opportunity to control high-energy but structurally unbiased cation intermediates such as the norbonyl cations.Beyond practical appeals such as good scalability as well as ease and modularity of preparation,the extremely low pre-catalyst loadings required to achieve high turnover and stereoselectivity have also come to define a new frontier in organocatalysis.
基金
We are grateful for financial support from the National Natural Science Foundation of China(21825105,21901105,22231004,22250410266)
National Key R&D Programof China(2021YFF0701604)
Guangdong Provincial Key Laboratory of Catalysis(2020B121201002)
Guangdong Innovative Program(2019BT02Y335)
Shenzhen Science and Technology Program(KQTD20210811090112004,JCYJ20210324120205016,JCYJ20210324105005015).
