摘要
刚地弓形虫是一种胞内寄生原虫,在世界范围内广泛存在,几乎可以感染所有的温血动物,严重危害人类及各种温血动物的健康。研究表明,弓形虫感染雄性动物会导致生殖系统的多方面损伤,包括组织器官损伤、激素代谢紊乱、细胞代谢调节等多方面稳态维护指标的改变以及精子结构和功能的损伤,是目前研究的热点和趋势。尽管近年来多项研究通过蛋白质组学和转录组学对弓形虫感染引起的雄性动物生殖障碍机制进行了探究,但弓形虫损害生殖机能的机制依旧不清晰。论文通过对近年来弓形虫对生殖细胞致病机制的相关研究进行回顾,在前人研究的基础上对弓形虫感染可能对雄性动物生殖机能造成的影响和分子机制进行讨论。
Toxoplasma gondii is a kind of intracellular parasitic protozoa,which exists widely in the world.It can infect almost all warm blooded animals and seriously endanger the health of human beings and all kinds of warm blooded animals.Studies have shown that Toxoplasma gondii infection in male animals can lead to various damage to the reproductive system,including tissue and organ damage,hormone metabolism disorder,cell metabolism regulation and other changes in steady-state maintenance indicators,as well as sperm structure and function damage,which is the current research hotspot and trend.Although in recent years,many studies have explored the mechanism of male reproductive dysfunction caused by Toxoplasma gondii infection through proteomics and transcriptomics,the mechanism of Toxoplasma gondii damaging reproductive function is still unclear.This paper reviews the recent studies on the pathogenic mechanism of Toxoplasma gondii on germ cells,and discusses the possible effects of Toxoplasma gondii infection on the reproductive function of male animals and the molecular mechanism on the basis of previous studies.
作者
魏世豪
林晓凤
张露
黄志坚
殷光文
王磊
WEI Shi-hao;LIN Xiao-feng;ZHANG Lu;HUANG Zhi-jian;YIN Guang-wen;WANG Lei(College of Animal Science,Fujian Agriculture and Forestry University/Fujian Animal Medicine Engineering Laboratory,Fuzhou,Fujian,350000,China)
出处
《动物医学进展》
北大核心
2023年第6期115-119,共5页
Progress In Veterinary Medicine
基金
国家自然科学基金项目(32102734)
福建省自然科学基金项目(2020J05024)
福建农林大学校级大学生创新训练项目(202210389117)
福建省教育厅中青年科研项项目(JAT210659)。
关键词
刚地弓形虫
弓形虫病
生殖功能
不育
雄性动物
Toxoplasma gondii
Toxoplasmosis
reproductive function
infertility
male animal
