摘要
目的 分析胃癌病人癌组织中纺锤体蛋白(SPIN1)、锌指转录因子(Slug)和紧密连接蛋白(Claudin-1)三种蛋白的表达情况与其临床病理特征的相关性。方法 选取贵州医科大学附属医院2019年6月至2021年7月确诊并收治的84例胃癌病人,按照分期分为对照组(早期胃癌)和实验组(晚期胃癌)两组,使用ELISA检测胃癌组织中的SPIN1、Slug和Claudin-1三种蛋白表达情况并分析其间的关系。结果 两组病人在一般资料上差异无统计学意义(P>0.05),在年龄、饮酒史和胃部疾病上差异有统计学意义(P<0.05),实验组胃癌病人SPIN1和Slug显著高于对照组胃癌病人(P<0.05),且实验组Claudin-1显著低于对照组胃癌病人(P<0.05),对照组和实验组的肿瘤长径[≥5 mm:4(9.52%)比32(76.19%)]、是否存在淋巴结转移[阳性:5(11.90%)比37(88.10%)]之间均差异有统计学意义(P<0.05)。结论 胃癌病人SPIN1、Slug和Claudin-1的表达情况与胃癌分期和肿瘤长径与临床病理特征之间存在一定相关性。
Objective To analyze the correlation between the expression of three proteins,spindle protein(SPIN1),zinc finger transcription factor(Slug)and tight junction protein(Claudin-1),and their clinicopathological features in tumor tissues of gastric tumor patients.Methods A total of 84 gastric tumor patients diagnosed and admitted to the Affiliated Hospital of Guizhou Medical University from June 2019 to July 2021 were selected and divided into two groups according to stage:the control group(early gastric tumor)and the experimental group(advanced gastric tumor).ELISA was used to detect the expression of three proteins,SPIN1,Slug and Claudin-1,in gastric tumor tissues and to analyze the relationship between them.Results There was no significant difference in general data between the two groups(P>0.05)and statistically significant differences in age,history of alcohol consumption and gastric diseases(P<0.05).SPIN1 and Slug were significantly higher in the experimental group than in the control group(P<0.05),and claudin-1 was significantly lower in the experimental group than in the control group(P<0.05).The differences between the tumor diameter[5 mm:4(9.52%)than 32(76.19%)]and the presence of lymph node metastasis[positive:5(11.90%)and 37(88.10%)]were significant(P<0.05).Conclusion The expression of SPIN1,Slug and Claudin-1 in gastric tumor patients correlated with gastric tumor stage,tumor size and clinicopathological features.
作者
张子杭
成元华
李小梅
ZHANG Zihang;CHENG Yuanhua;LI Xiaomei(Pathology Teaching and Research Section,Clinical Medical College,Guizhou Medical University,Guiyang,Guizhou 550004,China;Department of Pathology,Affiliated Hospital of Guizhou Medical University,Guiyang,Guizhou 550004,China)
出处
《安徽医药》
CAS
2023年第6期1159-1161,共3页
Anhui Medical and Pharmaceutical Journal
基金
贵州省科技计划(黔合科J字[2009]2187)。
