摘要
目的 探究FeNO、NLR联合肺功能对哮喘急性发作患者病情评估的预测价值。方法分析2019年8月到2022年10月合肥京东方医院收治的96例哮喘急性发作患者的临床资料,根据患者的病情严重程度,将患者分为轻度及中度和重度及危重度组,对比两组患者的FeNO、NLR及肺功能,采用Pearson相关性分析FeNO、NLR、肺功能与哮喘急性发作患者病情严重程度的相关性;并绘制受试者工作曲线(ROC),分析FeNO、NLR联合肺功能对哮喘急性发作患者病情评估的预测价值。结果轻度及中度组患者的FeNO、NLR水平明显低于重度及危重度组,肺功能(FEV1/FVC、FEV1%pred)均明显高于重度及危重度组,差异具有统计学意义(t=4.401,3.199,6.066、7.518;P<0.05)。Pearson相关分析显示,FeNO、NLR水平与哮喘急性发作患者病情严重程度呈正相关关系,与肺功能指标(FEV1/FVC、FEV1%pred)呈负相关关系(r=0.382,0.348,-0.412、-0.426;P<0.05)。ROC曲线分析结果显示,FeNO、NLR、肺功能预测患者病情的曲线下面积分别为0.728,0.681,0.812、0.875,联合预测曲线下面积为0.948。结论 FeNO、NLR联合肺功能对哮喘急性发作患者病情评估的预测价值较高,可为临床诊断和治疗哮喘急性发作病情的评估提供参考。
Objective To explore the predictive value of FeNO and NLR combined lung function in patients with acute asthma attack.Methods Retrospective analysis was performed on the clinical data of 96 patients with acute asthma attack admitted to Hefei BOE Hospital from August 2019 to October 2022.According to the severity of the patients,the patients were divided into the mild and moderate groups and the severe and critical groups.FeNO,NLR and lung function between the two groups were compared.Pearson correlation was used to analyze the correlation between FeNO,NLR,lung function and severity of acute asthma.Receiver operating curve(ROC)was plotted to analyze the predictive value of FeNO and NLR combined lung function in the assessment of patients with acute asthma attack.Results The levels of FeNO and NLR in the mild and moderate groups were significantly lower than those in the severe and critical groups,and the lung function(FEV1/FVC,FEV1% pred)were significantly higher than those in the severe and critical groups,and the difference was statistically significant(t=4.401,3.199,6.066,7.518;P<0.05).Pearson correlation analysis showed that FeNO and NLR levels were positively correlated with the severity of acute asthma attacks,and negatively correlated with pulmonary function indicators(FEV1/FVC,FEV1%pred)(r=0.382,0.348,-0.412,-0.426;P<0.05).The ROC curve analysis results showed that the areas under the curve of FeNO,NLR and lung function prediction were 0.728,0.681,0.812 and 0.875,respectively,and the areas under the combined prediction curve were 0.948.Conclusion FeNO and NLR combined with lung function have a high predictive value in the assessment of patients with acute asthma attack,which can provide a reference for clinical diagnosis and treatment of acute asthma attack.
作者
徐晓梅
舒冬冬
李莉
宋乃宝
黄婷婷
潘良东
XU Xiaomei;SHU Dongdong;LI Li;SONG Naibao;HUANG Tingting;PAN Liangdong(Department of Respiratory Medicine,Hefei Jing Dong Hospital,Hefei,China,230013)
出处
《分子诊断与治疗杂志》
2023年第4期639-642,共4页
Journal of Molecular Diagnostics and Therapy
基金
安徽省重点研究和开发计划项目(201904a07020012)。
关键词
呼出气一氧化氮
NLR
肺功能
哮喘急性发作
病情评估
Fractional exhaled nitric oxide
NLR
Lung function
Acute asthma attack
Condition assessment
