摘要
目的:观察消炎利胆片辅助腹腔镜胆囊切除术治疗急性结石性胆囊炎的临床疗效及其对血清超敏C-反应蛋白(hs-CRP)、降钙素原(PCT)水平的影响。方法:选择行腹腔镜胆囊切除术的急性结石性胆囊炎患者78例作回顾性分析,根据治疗方式的不同分为对照组和观察组各39例。对照组采用腹腔镜胆囊切除术治疗,观察组在腹腔镜胆囊切除术治疗的基础上加用消炎利胆片治疗。比较2组临床疗效、术后症状改善时间、不良反应发生率和治疗前后中医证候评分、hs-CRP、PCT水平。结果:观察组总有效率为94.87%,对照组为79.48%,2组比较,差异有统计学意义(P<0.05)。观察组肠鸣音恢复时间、首次排气时间、首次排便时间、住院时间均较对照组短,差异有统计学意义(P<0.05)。治疗后,2组上腹疼痛、压痛、晨起口苦、恶心呕吐、持续低热、身目黄染、舌红苔黄等中医证候评分均较治疗前降低(P<0.05),且观察组各项中医证候评分均低于对照组(P<0.05)。治疗后,观察组血清hs-CRP、PCT水平均低于治疗前及对照组(P<0.05),而对照组上述2项指标治疗前后差异均无统计学意义(P>0.05)。观察组不良反应发生率为7.69%,对照组为20.51%,2组比较,差异无统计学意义(P>0.05)。结论:消炎利胆片联合腹腔镜胆囊切除术治疗急性结石性胆囊炎可提高临床疗效,显著降低中医证候评分和不良反应发生率,缩短术后胃肠功能恢复时间,下调血清hs-CRP、PCT水平,且安全性较高。
Objective:To observe the clinical effect of Xiaoyan Lidan Tablets assisting laparoscopic cholecystectomy on acute calculous cholecystitis and its effect on high-sensitive C-reactive protein(hs-CRP)and the level of procalcitonin(PCT).Methods:A total of 78 patients with acute calculous cholecystitis treated with laparoscopic cholecystectomy were analyzed retrospectively and divided into the control group and the observation group according to different treatment methods,with 39 cases in each group.The control group was given the laparoscopic cholecystectomy,and the observation group was additionally treated with oral administration of Xiaoyan Lidan Tablets based on the treatment of the control group.The clinical effects,improvement time of symptoms after surgery,incidence of adverse reactions as well as the traditional Chinese medicine(TCM)syndrome scores and levels of hs-CRP and PCT were compared between the two groups before and after treatment. Results: The total effective rate was94.87% in the observation group,and 79.48% in the control group,the difference being significant (P<0.05). The recovery time of bowel sound,first exhaust time,first defecation time and hospitalization timein the observation group were shorter than those in the control group,the difference being significant (P<0.05). After treatment,the TCM syndrome scores of pain in upper abdomen,tenderness,bitter taste inthe morning,nausea and vomiting,continuous low-grade fever,yellow skin and eyes,and red tongueand yellow coating in both groups were decreased when compared with those before treatment (P<0.05),and the above seven scores in the observation group were lower than those in the control group (P<0.05).After treatment, the levels of hs- CRP and PCT in the observation group were lower than those in thecontrol group and before treatment (P<0.05), and there was no significant difference being found in thecomparisons of above two indexes in the control group before and after treatment (P>0.05). The incidenceof adverse reactions was 7.69% in the observation group,and 20.51% in the control group,there being nosignificance in the difference (P>0.05). Conclusion: Xiaoyan Lidan Tablets combined with laparoscopiccholecystectomy for acute calculous cholecystitis can enhance the curative effect, shorten the recoverytime of gastrointestinal function,and decrease the levels of hs-CRP and PCT,with better safety.
作者
陈周明
张坤
谭炜
张胜娟
CHEN Zhouming;ZHANG Kun;TAN Yi;ZHANG Shengjuan
出处
《新中医》
CAS
2023年第8期100-104,共5页
New Chinese Medicine
关键词
急性结石性胆囊炎
腹腔镜胆囊切除术
消炎利胆片
超敏C-反应蛋白
降钙素原
Acute calculous cholecystitis
Laparoscopic cholecystectomy
Xiaoyan Lidan Tablets
High-sensitive C-reactive protein
Procalcitonin
