摘要
目的:通过数据挖掘方法探索口服中药治疗白癜风海量专利的复方组合规律,为临床治疗和传承研发提供参考。方法:检索《中国专利全文数据库(知网版)》中的专利,选取建库至2021年8月31日,符合以口服中药治疗白癜风的专利,对所得药物组合及其性味归经进行频数分析、聚类分析、关联规则分析。结果:筛选共得专利组合145个,涉及中药370味,分析使用频次≥18次的高频中药28味,含当归、白蒺藜、补骨脂、何首乌、丹参、川芎、甘草、红花、生黄芪、白芷等。口服中药关键功效为活血化瘀、补血、补阳、补阴、补气,药性以温、微温、平性为主,药味以甘,辛、苦为主,归经多为肝、心、脾、肾经。专利复方组合以补肾填精养血祛风、和血、凉血解毒等为主。分析得主要核心组合40个;聚类分析共6类。结论:总结专利中白癜风内治法单药及复方组合规律,并进一步分析,为临床口服中药治疗白癜风的遣方用药、传承研发提供参考。
Objective:To explore the compound combination law of massive patents of oral traditional Chinese medicine for the treatment of vitiligo through the data mining method,so as to provide a reference for clinical treatment,inheritance,and research and development.Methods:The patents in China HowNet patent database were searched,and those meeting the requirements of oral traditional Chinese medicine for the treatment of vitiligo were selected from the establishment of the database to August 31,2021.Frequency analysis,cluster analysis,and association rule analysis were conducted on the obtained drug combinations and their properties,tastes,and meridians.Results:A total of 145 patent combinations were screened,involving 370 herbs.28 kinds of high-frequency traditional Chinese medicine with a frequency of use no less than 18 were analyzed,including Angelica Sinensis,Tribulus Terrestris,Psoralea Corylifolia,Radix Polygoni Multiflori,Salvia Miltiorrhiza,Ligusticum Chuanxiong,Radix Glycyrrhiza,Carthamus Tinctorious,Membranous Milkvetch Root,Angelica Dahurica,etc.The key efficacy of oral traditional Chinese medicine is to activate blood circulation,remove blood stasis,and replenish blood,Yang,Yin,and Qi.The medicinal properties are mainly warm,mild,and plain,and the medicinal tastes are mainly sweet,pungent,and bitter.The meridians are mostly liver,heart,spleen,and kidney meridians.The compound combination with patent mainly focuses on tonifying the kidney,filling essence,nourishing blood,expelling wind,harmonizing blood,cooling blood,and detoxifying.Up to 40 core combinations were obtained.Cluster analysis included six kinds.Conclusion:The combination law of single drug and compound drugs for vitiligo internal treatment in the patents was summarized and further analyzed,so as to provide a reference for the prescription,inheritance,and research and development of clinical oral traditional Chinese medicine for the treatment of vitiligo.
作者
张鹏
曲剑华
ZHANG Peng;QU Jianhua(Graduate School,Beijing University of Traditional Chinese Medicine,Beijing 100029,China;Department of Dermatology,Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China)
出处
《世界中医药》
CAS
2023年第9期1287-1291,1297,共6页
World Chinese Medicine
基金
国家重点研发计划项目(2018YFC1704102)——“基于‘道术结合’思路与多元融合方法的名老中医经验传承创新研究”课题东部地区名老中医学术观点、特色诊疗方法和重大疾病防治经验研究
国家中医药管理局第二批流派传承工作室(LPGZS2012-03)——“燕京赵氏皮科流派传承作室”项目。
关键词
白癜风
氧化应激
专利
口服中药
数据挖掘
用药规律
药理学
天然抗氧化剂
Vitiligo
Oxidative stress
Patent
Oral traditional Chinese medicine
Data mining
Medication rule
Pharmacology
Natural antioxidants
