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钠-葡萄糖共转运蛋白2抑制剂在改善胰岛素抵抗和胰岛β细胞功能方面的研究进展

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摘要 钠-葡萄糖共转运蛋白2抑制剂(SGLT-2i)是近年来研制的新型降糖药物,现已广泛用于2型糖尿病(T2DM)的治疗。近年多项研究结果显示SGLT-2i不仅可有效降低血糖,改善血压和血脂,对心血管系统和肾脏起到一定保护作用,还可改善T2DM患者的胰岛素抵抗(IR)和胰岛β细胞功能。本文将对其改善IR和胰岛β细胞功能的可能机制进行阐述。
作者 张越 王丽宏
出处 《临床内科杂志》 CAS 2023年第3期213-215,共3页 Journal of Clinical Internal Medicine
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