摘要
目的分析吲哚美辛栓对剖宫产产妇术后疼痛缓解促进术后恢复的作用。方法选取2021年6月至2022年3月在中国航空工业3201医院产科进行剖宫产分娩的280例产妇作为研究对象,采用简单随机法分为两组。对照组140例给予硬膜外自控镇痛泵镇痛,观察组给予吲哚美辛栓肛塞镇痛。比较两组疼痛和舒适程度评分、术后一般情况,检测两组疼痛介质、泌乳素(PRL)水平差异。结果观察组术后4、6、12、24、48 h时的舒适度(BCS)评分高于对照组,差异有统计学意义(P<0.05)。术后3 d,两组血清P物质(SP)、5-羟色胺(5-HT)较术后1 d下降,β-内咖肽(β-EP)较术后1 d升高,但两组疼痛介质比较,差异无统计学意义(P>0.05)。观察组肛门排气、自主排尿及初乳时间均短于对照组,24 h阴道出血量与对照组比较,差异无统计学意义(P>0.05)。观察组术后30 min、24 h、48 h的PRL均高于对照组(P<0.05)。两组不良反应率比较,差异无统计学意义(P>0.05)。结论吲哚美辛栓用于剖宫产产妇术后,可达到与硬膜外自控镇痛泵同样镇痛效果,在促进胃肠功能恢复和泌乳方面更突出。
Objective To analyze the effect of indomethacin suppository on postoperative pain relief of cesarean section and promoting postoperative recovery.Methods 280 parturients delivered by cesarean section in the Obstetrics Department of AVIC 3201 Hospital from June 2021 to March 2022 were selected as the research objects,and divided into two groups by simple random method.140 cases in the control group were given epidural patient-controlled analgesia pump for analgesia,while 140 cases in the observation group was given indomethacin suppository for anal analgesia.The pain and comfort scores,general postoperative conditions,pain mediators and prolactin(PRL)levels were compared between the two groups.ResultsThe BCS scores at 4 h,6 h,12 h,24 h and 48 h afer operation in the observation group were higher than those in the control group(P<0.05).On the 3rd day after operation,the levels of substance P(SP)and 5-hydroxytryptamine(5-HT)in serum of the two groups decreased compared with that on the 1st day after operation,β-Endocaffein(β-EP)was higher than 1 day after operation,with no significant difference between the two groups in pain media(P>0.05).The time of anal exhaust,autonomous urination and colostrum in the observation group was shorter than that in the control group,with no significant difference in the amount of vaginal bleeding within 24 hours(P>0.05).The PRL at 30 min,24 h and 48 h after operation in the observation group was higher than that in the control group(P<0.05).There was no significant difference in adverse reaction rate between the two groups(P>0.05).Conclusion Indomethacin suppository can achieve the same analgesic effect as the patient-controlled epidural analgesia pump after cesarean section,and is more prominent in promoting gastrointestinal function recovery and lactation.
作者
王小莎
宁苗
黄姝峰
WANG Xiaosha;NING Miao;HUANG Shufeng(Department of Obstetrics,3201 Hospital of Aviation Industry of China,Hanzhong Shanxi 723000,China)
出处
《中国妇产科临床杂志》
CSCD
2023年第3期261-263,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
基金
陕西省社会科学基金项目(3201yk201701)。
关键词
吲哚美辛栓
剖宫产
疼痛
舒适度
胃肠功能
泌乳
indomethacin suppository
cesarean section
pain
comfort
gastrointestinal function
lactation
