摘要
目的探讨胎盘SLC16A1基因及单羧酸转运蛋白1(MCT1)表达量与妊娠期糖尿病(GDM)的关系。方法选取该院1361例妊娠女性为研究对象,其中GDM患者281例纳入GDM组,健康妊娠女性1080例纳入正常妊娠组。正常妊娠组及GDM组按1∶1匹配(n=105)后比较两组胎盘MCT1及SLC16A1基因表达量,并采用Logistic回归分析MCT1及SLC16A1基因表达量与GDM的关系。匹配参数为体质量指数、年龄、生产史、GDM病史(匹配容差分别为0.3、0、0、0)。结果GDM组、正常妊娠组SLC16A1基因表达量分别为0.390(0.006,2.980)、0.561(0.014,4.205),GDM组明显低于正常妊娠组,差异有统计学意义(P<0.05)。GDM组、正常妊娠组MCT1表达量分别为0.097±0.044、0.166±0.030,GDM组明显低于正常妊娠组,差异有统计学意义(P<0.05)。Logistic回归分析显示SLC16A1基因表达量增加是GDM的保护因素(OR=0.740,95%CI 0.561~0.974,P<0.05)。结论GDM患者胎盘SLC16A1基因及MCT1表达量均下降,SLC16A1基因表达量增加是GDM的保护因素。
Objective To investigate the relationships between the expression of placenta SLC16A1 gene,monocarboxylate transporter 1(MCT1)and gestational diabetes mellitus(GDM).Methods A total of 1361 pregnant women in Shanghai Fifth People′s Hospital,Fudan University were selected as subjects,including 281 patients with GDM(GDM group)and 1080 healthy pregnancy women(normal pregnancy group).The expression levels of MCT1 and SLC16A1 gene in normal pregnancy group and GDM group were compared after 1∶1 matching(n=105),and the relationships between the expression levels of MCT1,SLC16A1 gene and GDM were analyzed by Logistic regression.The matching parameters were body mass index,age,birth history and GDM history(matching tolerances were 0.3,0,0,0 respectively).Results The SLC16A1 gene expression in GDM group and normal pregnancy group were 0.390(0.006,2.980)and 0.561(0.014,4.205)respectively,and which in GDM group was significantly lower than that in normal pregnancy group,the difference was statistically significant(P<0.05).The expression level of MCT1 in GDM group and normal pregnancy group were 0.097±0.044 and 0.166±0.030 respectively,which in GDM group was significantly lower than that in normal pregnancy group,the difference was statistically significant(P<0.05).Logistic regression analysis showed that the increased expression level of SLC16A1 gene was a protective factor for GDM(OR=0.740,95%CI 0.561—0.974,P<0.05).Conclusion The expression of SLC16A1 gene and MCT1 decrease in GDM patients,the increased expression level of SLC16A1 gene is a protective factor for GDM.
作者
张瑞
杨倩
柯文才
黄新梅
吴跃跃
李悦
臧淑妃
刘军
ZHANG Rui;YANG Qian;KE Wencai;HUANG Xinmei;WU Yueyue;LI Yue;ZANG Shufei;LIU Jun(Department of Endocrinology,Shanghai Fifth People′s Hospital,Fudan University,Shanghai 200240,China)
出处
《检验医学与临床》
CAS
2023年第10期1374-1378,共5页
Laboratory Medicine and Clinic
基金
上海市闵行区自然科学基金项目(2019MHZ066)。
