摘要
目的探讨肝细胞癌(hepatocellular carcinoma,HCC)组织NAD依赖性蛋白脱乙酰基酶sirtuin-6(SIRT6)表达与HCC合并门静脉癌栓患者术后FOLFOX4化疗预后的相关性。方法选取2015年1月至2018年12月我院收治的85例HCC合并门静脉癌栓患者作为研究对象,术后均接受FOLFOX4化疗。采用免疫组织化学法检测HCC组织中蛋白SIRT6表达水平进行,采用单因素和多因素Cox回归分析影响HCC合并门静脉癌栓患者预后的独立影响因素。采用Kaplan-Meier法分析SIRT6表达水平与患者预后之间的关系。结果SIRT6在HCC组织中的表达水平高于癌旁组织(P<0.05)。采用单因素和多因素Cox回归分析显示,TNM分期、肝硬化、淋巴结转移、Child-Pugh分级以及SIRT6表达水平是影响HCC合并门静脉癌栓患者术后FOLFOX4化疗预后的独立因素(P<0.05)。Kaplan-Meier生存曲线显示,SIRT6低表达组的中位生存时间37.2个月(95%CI:28.7~46.2个月)长于SIRT6高表达组29.7个月(95%CI:20.2~38.5个月),差异有统计学意义(P<0.05)。结论SIRT6蛋白在HCC组织中呈高表达,是HCC合并门静脉癌栓患者术后FOLFOX4化疗预后的独立危险因素,有望成为预测HCC患者预后的新型生物标志物。
Objective To investigate the correlation between the expression of NAD-dependent protein deacetylase sirtuin-6(SIRT6)in hepatocellular carcinoma(HCC)tissues and the prognosis of postoperative FOLFOX4 chemotherapy in patients with HCC complicated with portal vein tumor thrombosis.Methods 85 patients with HCC complicated with portal vein tumor thrombosis admitted to our hospital from Jan.2015 to Dec.2018 were selected as the research subjects.They all received FOLFOX4 chemotherapy after surgery.Immunohistochemistry SP method was used to detect the expression level of protein SIRT6 in HCC tissues.The univariate and Cox regression were used to analyze the independent factors affecting the prognosis of patients with HCC complicated with portal vein tumor thrombosis.Kaplan-Meier method was used to analyze the relationship between SIRT6 expression level and prognosis.Results The expression level of SIRT6 in HCC tissues was higher than that in adjacent tissues(P<0.05).Univariate and multivariate Cox regression analysis showed that TNM stage,cirrhosis of liver,lymphatic metastasis,Child-Pugh classification and SIRT6 expression level were the factors affecting HCC complicated with portal vein tumor thrombus independent factors for the prognosis of patients after FOLFOX4 chemotherapy(P<0.05).Kaplan-Meier survival curve showed that the median survival time of the SIRT6 low expression group was longer than that of the SIRT6 high expression group[37.2 months(95%CI:28.7-46.2 months)vs 29.7 months(95%CI:20.2-38.5 months),P<0.05].Conclusion SIRT6 protein is highly expressed in HCC tissues,which is an independent risk factor for the prognosis of patients with HCC combined with portal vein tumor thrombus after FOLFOX4 chemotherapy,and is expected to become a new biomarker for predicting the prognosis of patients with HCC.
作者
王洁
万焱
郭玺
汤晓青
徐斌
WANG Jie;WAN Yan;GUO Xi;TANG Xiaoqing;XU Bin(Department of Medical Administration,The Third People's Hospital of Kunming,Kunming 650041,China;Department of Oncology,The Third People's Hospital of Kunming,Kunming 650041,China)
出处
《胃肠病学和肝病学杂志》
CAS
2023年第5期519-523,共5页
Chinese Journal of Gastroenterology and Hepatology
关键词
肝细胞癌
门静脉癌栓
FOLFOX4化疗
预后
相关性
Hepatocellular carcinoma
Portal vein tumor thrombus
FOLFOX4 chemotherapy
Prognosis
Correlation
