摘要
黄芪是大宗药材,有效成分主要包括多糖类、皂苷类和黄酮类。多糖类成分是黄芪中含量最多的活性成分,具有提高免疫力、抗衰老、改善记忆力等药理作用;皂苷类成分具有抗炎、免疫调节、抗氧化等作用;黄酮类成分具有显著的抗氧化、抗衰老等作用。黄芪有效成分的质量控制方法以高效液相色谱法最为常用,根据不同有效成分的特性可选用不同的检测器;另外,红外光谱法、色谱-质谱联用技术等也是其质量控制的有效方法。综述黄芪有效成分的药理作用及其质量控制研究进展,明确黄芪有效成分的药理作用并为黄芪各有效成分的质量控制提供参考和依据。
Astragali Radix is a kind of bulk medicinal materials,and its effective components mainly include polysaccharides,saponins and flavonoids.Among them,polysaccharides are the most active ingredients in Astragali Radix,which can improve immunity,anti-aging and memory.Saponins have anti-inflammatory,immunomodulatory and antioxidant effects.Flavonoids have significant antioxidant and anti-aging effects.High performance liquid chromatography is the most commonly used method for quality control of the effective components of Astragali Radix.Different detectors can be selected according to the characteristics of different effective components.In addition,infrared spectroscopy,chromatography-mass spectrometry are also effective methods for quality control.In this paper,pharmacological effects and quality research progress of effective components in Astragali Radix were reviewed,so as to clarify pharmacological effects of effective components and provide reference and basis for quality control of effective components in Astragali Radix.
作者
王祯
张俊令
焦宏基
刘婧
王晋乾
WANG Zhen;ZHANG Junling;JIAO Hongji;LIU Jin;WANG Jinqian(Peking Union Second Pharmaceutical Factory Co.,Ltd.,Beijing 102600,China)
出处
《药物评价研究》
CAS
2023年第4期917-924,共8页
Drug Evaluation Research
关键词
黄芪
皂苷类
多糖类
黄酮类
药理作用
质量研究
Astragali Radix
saponins
polysaccharides
flavonoids
pharmacological effects
quality research
