摘要
目的探讨经皮超声引导下细针穿刺活检组织中糖类抗原242(CA242)、肿瘤特异性生长因子(TSGF)联合检测对胰腺癌的诊断价值。方法选取92例胰腺癌患者和50例慢性胰腺炎患者,分别作为观察组和对照组。所有患者均行经皮超声引导下细针穿刺活检和血清肿瘤标志物检测,比较两组患者血清和经皮超声引导下细针穿刺活检组织中CA242、TSGF水平。比较血清和经皮超声引导下细针穿刺活检组织中CA242、TSGF单独及联合检测对胰腺癌的诊断价值,分析二者与胰腺癌患者预后的关系。结果142例患者中19例首次活检取材不满意,11例接受二次取材后仍有1例取材不满意,但未进行再次取材,共进行153次穿刺活检。观察组患者血清和经皮超声引导下穿刺活检组织中CA242、TSGF水平均明显高于对照组,且两组患者经皮超声引导下穿刺活检组织中CA242、TSGF水平均明显高于血清,差异均有统计学意义(P﹤0.01)。经皮超声引导下穿刺活检组织中CA242、TSGF单独及联合检测诊断胰腺癌的灵敏度、特异度均高于血清样本。随着临床分期的增高,胰腺癌患者血清与穿刺活检组织中CA242、TSGF水平均不断升高(P﹤0.05)。92例胰腺癌患者中,复发54例,无复发38例,所有复发患者中,42例(77.78%)患者CA242水平增高,45例(83.33%)患者TSGF水平增高。结论经皮超声引导下细针穿刺活检组织中CA242、TSGF联合检测对胰腺癌的诊断价值较高,且二者还与胰腺癌患者的预后密切相关,临床应加强对患者CA242、TSGF水平的监测。
Objective To explore the diagnostic value of combined detection of carbohydrate antigen 242(CA242)and tumor specific growth factor(TSGF)in percutaneous ultrasound-guided fine needle biopsy for pancreatic cancer.Method A total of 92 patients with pancreatic cancer and 50 patients with chronic pancreatitis were selected as observation group and control group respectively.All patients underwent percutaneous ultrasound-guided fine-needle aspiration biopsy and serum tumor markers detection.The levels of CA242 and TSGF in serum and percutaneous ultrasound-guided fine-needle aspiration biopsy were compared between the two groups.To compare the diagnostic value of CA242 and TSGF in serum and percutaneous ultrasound-guided fine-needle aspiration biopsy for pancreatic cancer,and to analyze the relationship between CA242 and TSGF and the prognosis of pancreatic cancer patients.Result The first biopsy sampling for 19 patients was not satisfied among 142 patients,and 1 case was still not satisfied with the second biopsy sampling for 11 patients,but not further sampling was performed,a total of 153 needle biopsies were performed.The levels of CA242 and TSGF in serum and percutaneous ultrasound-guided fine needle biopsy in observation group were higher than those in control group(P<0.01),with higher levels in biopsies than those in serum in both groups(P<0.01).The sensitivity and specificity of single and combined detection of CA242 and TSGF in biopsy were higher than those in serum,and the levels of CA242 and TSGF in serum and biopsy of pancreatic cancer patients increased by the increase of clinical stages(P<0.05).Among 92 patients with pancreatic cancer,54 patients relapsed and 38 patients did not relapse.Among all relapsed patients,42 patients(77.78%)had higher levels of CA242 and 45 patients(83.33%)had higher levels of TSGF.Conclusion The combined detection of CA242 and TSGF in percutaneous ultrasound-guided fine needle aspiration biopsy is of high diagnostic value for pancreatic cancer,and they are also closely related to the prognosis of patients with pancreatic cancer.Clinical monitoring of the levels of CA242 and TSGF in patients should be strengthened.
作者
吉婷婷
王玲玲
史良玉
JI Tingting;WANG Lingling;SHI Liangyu(Department of Gastroenterology,No.215 Hospital of Shaanxi Nuclear Industry,Xianyang 712000,Shaanxi,China)
出处
《癌症进展》
2023年第7期794-798,共5页
Oncology Progress
关键词
细针穿刺活检组织
胰腺癌
糖类抗原242
肿瘤特异性生长因子
fine needle aspiration biopsy
pancreatic cancer
carbohydrate antigen 242
tumor specific growth factor
