摘要
目的 探讨因甲状腺结节行手术治疗者吸烟状态与甲状腺乳头状癌(PTC)发生风险的相关性。方法 收集2016年1月-2020年12月因甲状腺结节在解放军总医院第一医学中心行手术切除且术后病理资料完整的5938例患者的临床资料进行回顾性分析,其中PTC 5156例,良性结节782例。比较PTC组与良性结节组患者的一般资料、血清促甲状腺激素(TSH)水平、甲状腺自身抗体水平及病理特征等,并比较不同吸烟状态患者的临床及病理特点。采用二元logistic回归分析总体及不同性别患者吸烟状态与PTC发生风险的相关性。结果 PTC组与良性结节组吸烟者占比差异无统计学意义(P=0.104)。按性别分组后,男性PTC组吸烟者占比明显低于良性结节组(P<0.05);两组女性吸烟者占比差异无统计学意义(P>0.05)。Logistic回归分析显示,与不吸烟者比较,吸烟者发生PTC的风险更低(OR=0.735,95%CI0.564~0.959);基于性别分组后,仅男性吸烟者发生PTC的风险更低(OR=0.635,95%CI0.449~0.896),女性则未见明显相关性(OR=0.910,95%CI 0.417~1.986)。结论 因甲状腺结节行手术治疗的患者中,男性吸烟可能与PTC的发生风险降低有关。
Objective To explore the correlation between smoking status and the risk of papillary thyroid carcinoma(PTC)in patients undergoing surgical treatment for thyroid nodules.Methods A retrospective analysis was conducted with the clinical data of 5938 patients(5156 cases with PTC and 782 cases with benign nodules)who underwent surgical resection of thyroid nodules in the First Medical Center of Chinese PLA General Hospital from January 2016 to December 2020,and with complete postoperative pathological results.The general information,serum thyroid hormone(TSH)level,thyroid autoantibody level,and the clinical and pathological characteristics of patients with different smoking status were compared between the two groups.The correlation between smoking status and the risk of PTC in patients of different genders and overall population were analyzed using binary logistic regression analysis.Results There no significant difference in percentage of smokers between PTC group and benign nodule group(P=0.104).The PTC group had a significantly lower proportion of smokers than the benign nodule group for males(P<0.05)rather than for females(P>0.05).For all patients,smokers had a lower proportion of PTC than non-smokers(OR=0.735,95%CI 0.564-0.959)after adjustment for confounders.In the gender subgroup analysis,a lower risk of PTC was found in smokers than in non-smokers among men(OR=0.635,95%CI 0.449-0.896),while no association was observed among women(OR=0.910,95%CI 0.417-1.986)after adjustment for confounders.Conclusion Smoking in males may be associated with a reduced risk of developing PTC in patients undergoing surgical treatment for thyroid nodules.
作者
许怀瑾
胡晓东
李洁菲
聂智梅
康韶洋
赵思童
柳洪宙
王玉寒
王安宁
吕朝晖
Xu Huai-Jin;Hu Xiao-Dong;Li Jie-Fei;Nie Zhi-Mei;Kang Shao-Yang;Zhao Si-Tong;Liu Hong-Zhou;Wang Yu-Han;Wang An-Ning;Lv Zhao-Hui(Department of Endocrinology,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China;School of Medicine,Nankai University,Tianjin 300071,China)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2023年第5期516-522,共7页
Medical Journal of Chinese People's Liberation Army
关键词
吸烟
甲状腺乳头状癌
甲状腺结节
smoking
papillary thyroid carcinoma
thyroid nodule
