摘要
目的:观察拉莫三嗪联合丙戊酸钠治疗癫痫患儿的效果。方法:选取2019年1月至2021年12月该院收治的98例癫痫患儿进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各49例。对照组予以丙戊酸钠治疗,观察组在对照组基础上联合拉莫三嗪治疗,比较两组治疗前和治疗3、6个月时癫痫发作次数、血清炎性因子[超敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、肿瘤坏死因子-α(TNF-α)]水平、脑神经损伤指标[S100β蛋白、神经元特异性烯醇化酶(NSE)、胰岛素样生长因子-1(IGF-1)]水平,以及不良反应发生率。结果:治疗3、6个月时,观察组癫痫发作次数均少于对照组,差异有统计学意义(P<0.05);观察组hs-CRP、Hcy、TNF-α、S100β蛋白、NSE、IGF-1水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:拉莫三嗪联合丙戊酸钠治疗癫痫患儿可减少癫痫发作次数,降低血清炎性因子和脑神经损伤指标水平,效果优于单纯丙戊酸钠治疗。
Objective:To observe effects of Lamotrigine combined with Sodium valproate in treatment of children with epilepsy.Methods:A prospective study was conducted on 98 children with epilepsy admitted to the hospital from January 2019 to December 2021.They were divided into control group and observation group according to the random number table method,49 cases in each.The control group was treated with Sodium valproate,while the observation group was treated with Lamotrigine on the basis of that of the control group.The number of seizures,the serum inflammatory factors[high-sensitivity C-reactive protein(hs-CRP),homocysteine(Hcy),tumor necrosis factor-α(TNF-α)]levels,the brain nerve injury indicators[S-100βprotein,neuron-specific enolase(NSE),insulin-like growth factor-1(IGF-1)]levels,and incidence of adverse reactions were compared between the two groups before and 3 and 6 months after the treatment.Results:3 and 6 months after the treatment,the number of seizures in the observation group was less than that in the control group,and the difference was statistically significant(P<0.05).The levels of hsCRP,Hcy,TNF-α,S-100βprotein,NSE and IGF-1 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Lamotrigine combined with Sodium valproate in the treatment of the children with epilepsy can reduce the number of seizures,and reduce the levels of serum inflammatory factors and the brain nerve injury indicators.Moreover,it is superior to single Sodium valproate treatment.
作者
侯彦杰
HOU Yanjie(Department of Pediatrics of Qi County People’s Hospital,Kaifeng 475201 Henan,China)
出处
《中国民康医学》
2023年第8期49-51,55,共4页
Medical Journal of Chinese People’s Health
关键词
癫痫
儿童
丙戊酸钠
拉莫三嗪
炎性因子
脑神经损伤
Epilepsy
Children
Sodium valproate
Lamotrigine
Inflammatory factor
Brain nerve injury
