摘要
目的:分析D-二聚体(D-D)、凝血指标联合检测在妊娠期高血压疾病诊断中的效能。方法:回顾性分析2018年2月至2021年2月该院收治的68例妊娠期高血压疾病患者的临床资料,纳入研究组。另选取30例该院规律产检孕妇为对照组。两组均行D-D、凝血指标水平检测。比较两组D-D、凝血指标[凝血酶原时间(PT)、凝血酶时间(TT)、纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)]水平,并依据《妊娠期高血压疾病的定义及诊断变迁》,将研究组患者分为妊娠期高血压组26例、轻度子痫前期(PE)组24例、重度PE组18例,比较妊娠期高血压疾病各亚组间D-D、凝血指标水平,采用受试者工作特征曲线(ROC)分析D-D、凝血指标单项及联合检测在妊娠期高血压疾病诊断中的效能。结果:研究组PT、APTT、TT水平均低于对照组,FIB、D-D水平均高于对照组,差异有统计学意义(P<0.05);重度PE组PT、APTT、TT水平均低于轻度PE组与妊娠期高血压组,且轻度PE组低于妊娠期高血压组,重度PE组FIB、D-D水平均高于轻度PE组与妊娠期高血压组,且轻度PE组高于妊娠期高血压组,差异有统计学意义(P<0.05);D-D、凝血指标水平联合检测诊断妊娠期高血压疾病的曲线下面积(AUC)>0.9,诊断价值较高,且高于各单项检测。结论:D-D、凝血指标联合检测诊断妊娠期高血压疾病的效能高于各单项检测。
Objective:To analyze efficacy of combined detection of D-dimer(D-D)and coagulation index levels in diagnosis of hypertensive disorder complicating pregnancy.Methods:The clinical data of 68 patients with hypertensive disorder complicating pregnancy admitted to the hospital from February 2018 to February 2021 were retrospectively analyzed and included in study group.Another 30 pregnant women with regular prenatal examination in this hospital were selected as control group.The levels of D-D and coagulation indexes were detected in both groups.The levels of D-D and coagulation indexes[prothrombin time(PT),thrombin time(TT),fibrinogen(FIB),activated partial thromboplastin time(APTT)]were compared between the two groups.According to the definition and diagnostic changes of hypertensive disorder complicating pregnancy,the patients in the study group were divided into 26 cases of gestational hypertension group,24 cases of mild preeclampsia group and 18 cases of severe preeclampsia(PE)group.The levels of D-D and coagulation indexes were compared among these subgroups.The receiver operating characteristic curve(ROC)was used to analyze the efficacies of single and combined detection of D-D and coagulation index levels in the diagnosis of hypertensive disorder complicating pregnancy.Results:The levels of PT,APTT and TT in the study group were lower than those in the control group,the levels of FIB and D-D were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of PT,APTT and TT in the severe PE group were lower than those in the mild PE group and the gestational hypertension group,and those in the mild PE group were lower than those in the gestational hypertension group;the FIB and D-D levels in the severe PE group were higher than those in the mild PE group and the gestational hypertension group,and those in the mild PE group were higher than those in the gestational hypertension group;and the differences were statistically significant(P<0.05).The AUCs of combined detection of D-D and coagulation index levels in the diagnosis of hypertensive disorder complicating pregnancy was higher than 0.9,and the diagnostic value was higher than that of each single detection.Conclusions:The efficacy of combined detection of D-D and coagulation index levels in the diagnosis of hypertensive disorder complicating pregnancy is higher than that of single detection.
作者
葛卫卫
GE Weiwei(Department of Clinical Laboratory of Luohe Third People’s Hospital,Luohe Maternal and Child Health Hospital,Luohe 462000 Henan,China)
出处
《中国民康医学》
2023年第8期109-112,共4页
Medical Journal of Chinese People’s Health
