摘要
目的:系统评价阿维A联合中药治疗红皮病型银屑病的临床疗效及安全性。方法:检索中国知网、万方、维普、中国生物医学文献数据库、Pub Med、Embase等数据库中从建库至2022年5月发表的有关阿维A联合中药治疗红皮病型银屑病的文献,研究设计均为随机对照试验;运用Review Man 5.3软件对符合条件的文献进行Meta分析。结果:共纳入文献16篇,涉及病例总数1197例。总有效率:试验组优于对照组[OR=4.49,95%CI=(3.14,6.43),P<0.00001]。银屑病皮损面积和严重程度指数(Psoriasis Area and Severity Index,PASI)评分:试验组低于对照组[MD=-9.20,95%CI=(-11.06,-7.35),P<0.00001]。皮疹消退时间:试验组优于对照组[MD=-5.20,95%CI=(-5.99,-4.41),P<0.00001]。皮疹明显消退时间:试验组优于对照组[MD=-5.80,95%CI=(-6.85,-4.75),P<0.00001]。患者住院时间:试验组短于对照组[MD=-10.85,95%CI=(-12.19,-9.41),P<0.00001]。总不良反应发生率:试验组低于对照组[OR=0.40,95%CI=(0.31,0.53),P<0.00001]。复发率:试验组低于对照组[OR=0.33,95%CI=(0.19,0.59),P=0.0002],四组的差异均具有统计学意义。结论:阿维A联合中药治疗红皮病型银屑病的临床疗效及安全性优于单一阿维A治疗。由于本研究所纳入文献的质量有限且数量不足,故结论仍需高质量、大样本数据加以验证。
Objective:To evaluate the efficacy and safety of acitretin combined with TCM medicine on erythrodermic psoriasis.Methods:The literature related to the treatment of erythrodermic psoriasis with acitretin with TCM medicine published from the establishment of the database to May 2022 were searched from CNKI,Wanfang,VIP,CBM,PubMed,Embase and other foreign language databases.Review Man 5.3 software was used to compare the effects of acitretin combined with TCM medicine and single acitretin therapy.Results:Sixteen articles were included,with a total of 1197 cases.The result is shown that total effective rate in the experimental group was better than the control group[OR=4.49,95%CI=(3.14,6.43),P<0.00001].PASI score in the experimental group was lower than the control group[MD=-9.20,95%CI=(-11.06,-7.35),P<0.00001].Rash subsided time in the experimental group was better than the control group[MD=-5.20,95%CI=(-5.99,-4.41),P<0.00001].Rash rapid subsided time in the experimental group was better than the control group[MD=-5.80,95%CI=(-6.85,-4.75),P<0.00001].Hospitalization time in the experimental group was shorter than the control group[MD=-10.85,95%CI=(-12.19,-9.41),P<0.00001].The total incidence of adverse reactions in the experimental group was lower than the control group[OR=0.40,95%CI=0.31,0.53),P<0.00001].Recurrence rate in the experimental group was lower than the control group[OR=0.33,95%CI=(0.19,0.59),P=0.0002].The comparison of the four groups was statistically significant.Conclusion:The clinical efficacy and safety of acitretin combined with TCM medicine on erythrodermic psoriasis are better than single acitretin.Due to the limited quality and insufficient quantity of literature included in this study,the conclusion still needs to be verified by high-quality and large sample data.
出处
《中医临床研究》
2023年第8期141-148,共8页
Clinical Journal Of Chinese Medicine
基金
国家中医药管理局“2015年中医临床诊疗指南和治未病标准制修订”(SATCM-2015-BZ[284])
辽宁省教育厅一般项目(L2014363)。
