摘要
胃癌是消化系统最常见的恶性肿瘤之一。中药因其多靶点、多途径的抗肿瘤优势备受国内外学者关注。近期的研究结果显示,以黄酮类、酚类、生物碱和萜类为代表的中药有效成分,如槲皮素、白藜芦醇、莪术醇、人参皂苷和黄芩苷等,可通过调控Wnt/β-联蛋白、核因子κB、磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白、转录活化因子3、丝裂原活化蛋白激酶和Notch等信号通路,在抑制肿瘤细胞增殖、诱导恶性肿瘤细胞凋亡及迁移、抑制肿瘤血管生成等方面发挥有效作用,并协同增强化疗药的敏感性。本文梳理近年来的实验研究,探索中药有效成分治疗胃癌的相关信号通路,有助于为新药的研发、临床诊疗提供有效参考。
Gastric cancer is one of the most common malignant tumors in the digestive system.Traditional Chinese medicine has attracted the attention of scholars at home and abroad due to its multi-target and multi-pathway anticancer advantages.Recent studies have shown that small molecular compounds of traditional Chinese medicine represented by flavonoids,phenols,alkaloids and terpenoids,such as quercetin,resveratrol,curcumol,ginsenoside and baicalin,by regulating Wnt/β-catenin,nuclear factor-κB,phosphatidylinositol 3 kinase/protein kinase B/mammalian target of rapamycin,transcription activator 3,mitogen-activated protein kinase and Notch signaling pathways,it plays an effective role in inhibiting tumor cell proliferation,inducing apoptosis and migration of cancer cells,and inhibiting tumor angiogenesis,and synergistically enhancing the sensitivity of chemotherapy drugs.This article reviews the experimental studies in recent years and explores the related signaling pathways of the active components of traditional Chinese medicine in the treatment of gastric cancer,which is helpful to provide effective reference for the research and development of new drugs and clinical diagnosis and treatment.
作者
郭心怡
黄雅慧
赵丹
刘长兴
GUO Xinyi;HUANG Yahui;ZHAO Dan;LIU Changxing(The First Clinical Medical College,Shaanxi University of Traditional Chinese Medicine,Shaanxi Xianyang 712046,China;Dept.of Spleen and Stomach Diseases,Xi’an Traditional Chinese Medicine Hospital,Xi’an 710021,China)
出处
《中国医院用药评价与分析》
2023年第5期628-631,636,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
国家中医药管理局第六批全国老中医药专家学术经验继承工作项目(国中医药人教发〔2017〕29号)。
关键词
胃癌
中药有效成分
信号通路
作用机制
Gastric cancer
Active components of traditional Chinese medicine
Signal pathway
Mechanism
