摘要
疟色素的形成及其生物学意义一直存在争议。由于其与疟原虫生长、繁殖和致病密切相关,因此,疟色素的生物学功能需要进一步阐明。本文从其形态、产生的条件、形成的生物学功能、与宿主巨噬细胞的关系及其致病性等方面进行了初步的探讨,揭示了疟色素形成在虫体血红素和铁利用中的作用,以及在疟原虫进化、生长、繁殖中的特殊功能,为深入理解疟原虫致病机制以及研发抗疟新药提供思路。
The formation of the Plasmodium hemozoin and its biological significance has been controversial.Given that it is closely related to the growth,reproduction and pathogenicity of Plasmodium,the biological function of malarial hemozoin needs to be further elucidated.This article preliminarily discussed the morphology of hemozoin,the formation of hemozoin,the biological function of hemozoin,its relationship with the host macrophages,and its pathogenicity to reveal the role of the formation of hemozoin in the use of heme and iron,the unique function of hemozoin in the evolution,growth,and reproduction of malaria parasites,which helps to clarify the limitations of the traditional understanding of the Plasmodium hemozoin formation.It provides ideas for further understanding the pathogenic mechanism of Plasmodium and developing new antimalarial drugs.
作者
孙军
SUN Jun(Department of immunology and pathogenic biology,School of Medicine,Tongji University,Shanghai 200092,China)
出处
《中国寄生虫学与寄生虫病杂志》
CSCD
北大核心
2023年第2期209-212,共4页
Chinese Journal of Parasitology and Parasitic Diseases
基金
上海市教育委员会科研创新计划(201901070007E00017)。
关键词
疟原虫
疟色素
血红素
铁
Plasmodium
Malarial hemozoin
Heme
Iron
