摘要
目的探讨噻托溴铵粉吸入剂对慢性阻塞性肺疾病患者的临床疗效及对患者炎性因子的影响。方法本次收治山东省公共卫生临床中心的50例慢性阻塞性肺疾病患者作为研究的核心,以计算机软件将其分为对照组与观察组,对照组实施沙美特罗替卡松治疗,观察组开展沙美特罗替卡松+噻托溴铵粉吸入剂治疗,统计两组治疗效果、炎性因子与生活质量等。结果观察组治疗效果高于对照组,差异有统计学意义(P<0.05)。观察组在干预前的肺功能相关指标与对照组对比,差异显著,无统计学意义;干预后,观察组的肺功能相关指标与对照组进行对比,差别有统计学价值(P<0.05)。观察组炎性因子水平在干预前与对照组对比,差异不显著,无统计学意义;干预后,观察组炎性因子水平与对照组进行比较,差异显著,有统计学意义(P<0.05),观察组生活质量评分在干预后与对照组对比,差异显著(P<0.05)。结论沙美特罗替卡松+噻托溴铵粉吸入剂的应用,对患者的肺功能与生活质量改善有一定作用,且调整其炎症水平,促进其临床疗效的进一步提升。
Objective To explore the clinical efficacy of tiotropium bromide powder inhaler in patients with chronic obstructive pulmonary disease and its influence on inflammatory factors.Methods This time,50 patients with chronic obstructive pulmonary disease in Shandong Public Health Clinical Center were treated as the core of the study.They were divided into control group and observation group by computer software.The control group was treated with salmeterol xinafoate and fluticasone propionate.The observation group was treated with salmeterol xinafoate and fluticasone propionate plus tiotropium bromide powder inhaler.The treatment effect,inflammatory factors and quality of life of the two groups were statistically analyzed.Results The therapeutic effect of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05);After intervention,the indexes related to lung function in the observation group were compared with those in the control group,and the difference was statistically significant(P<0.05);After intervention,the level of inflammatory factors in the observation group was significantly different from that in the control group(P<0.05).Conclusion The application of salmeterol xinafoate and fluticasone propionate+tiotropium bromide powder inhaler can improve the lung function and quality of life of patients,adjust the level of inflammation and promote the further improvement of clinical efficacy.
作者
李亚力
阴娜
张笑弟
董文焱
LI Yali;YIN Na;ZHANG Xiaodi;DONG Wenyan(Department of Pharmaceutical,Shandong Public Health Clinical Center,Ji'nan 250102,China;Jinan Municipal People's Government Organs Outpatient Department,Ji'nan 250099,China)
出处
《中国医药指南》
2023年第15期9-12,共4页
Guide of China Medicine
关键词
噻托溴铵粉
吸入剂
慢性阻塞性肺疾病
临床疗效
炎性因子
Tiotropium bromide powder
Inhalant
Chronic obstructive pulmonary disease
Clinical efficacy
Inflammatory factor
