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sCD30在慢乙肝相关慢加急性肝衰竭诊断中的价值

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摘要 目的:研究sCD30检测在诊断慢性乙型病毒性肝炎(慢乙肝)相关慢加急性肝衰竭中的价值。方法:乙型病毒性肝炎相关慢加急性肝衰竭(ACLF)患者92例为HBV-ACLF组,同期在我院治疗的慢乙肝患者90例为慢乙肝组,同期我院体检的健康者90例为对照组。比较3组血浆sCD30水平,分析检测sCD30对慢乙肝及乙肝慢加急性肝衰竭诊断的敏感度和特异度。结果:对照组、慢乙肝组、HBV-ACLF组sCD30水平分别为18.6±10.2 ng/mL、20.6±10.8 ng/mL、52.4±35.1 ng/mL,3组差异具有统计学意义(P=0.000)。ACLF组sCD30水平高于对照组(P=0.000)和慢乙肝组(P=0.002),差异均有统计学意义。sCD30诊断慢乙肝的曲线下面积(AUC)为0.5578,敏感度为57%,特异度为71%;诊断HBV-ACLF患者的AUC为0.7678,敏感度为53%,特异度为80%。sCD30联合HBV-DNA检测诊断HBV-ACLF的AUC为0.7860,敏感度为63%,特异度为87%。结论:联合检测sCD30及HBV-DNA检测可为临床上诊断HBV-ACLF提供一定帮助。
出处 《交通医学》 2023年第2期154-158,162,共6页 Medical Journal of Communications
基金 南通市卫生健康委员会计划项目(WX2017001) 南通市科技局面上项目(MS22020014) 南通市科技计划指导性项目(MSZ20099)。
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  • 1M. Shadab Siddiqui,R. Todd Stravitz.Intensive Care Unit Management of Patients with Liver Failure[J]. Clinics in Liver Disease . 2014 (4)
  • 2Vallance P,Moncada S.Hyperdynamic circulation in cirrhosis: a role for nitric oxide?. The Lancet . 1991
  • 3Sen S,Davies NA,Mookerjee RP,et al.Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: a randomized controlled study. Liver Transplantation . 2004
  • 4Tripathi Dhiraj,Stanley Adrian J,Hayes Peter C,Patch David,Millson Charles,Mehrzad Homoyon,Austin Andrew,Ferguson James W,Olliff Simon P,Hudson Mark,Christie John M.UK guidelines on the management of variceal haemorrhage in cirrhotic patients[J]. Gut . 2015 (11)
  • 5Konstantina Sargenti,Hanne Prytz,Emma Nilsson,Sara Bertilsson,Evangelos Kalaitzakis.Bacterial infections in alcoholic and nonalcoholic liver cirrhosis[J]. European Journal of Gastroenterology & Hepatology . 2015 (9)
  • 6Konstantina Sargenti,Hanne Prytz,Emma Nilsson,Evangelos Kalaitzakis.Predictors of mortality among patients with compensated and decompensated liver cirrhosis: the role of bacterial infections and infection-related acute-on-chronic liver failure[J]. Scandinavian Journal of Gastroenterology . 2015 (7)
  • 7Yu Shi,Ming‐hua Zheng,Ying Yang,Wu Wei,Qiao Yang,Airong Hu,Yaoren Hu,Yihua Wu,Huadong Yan.Increased delayed mortality in patients with acute‐on‐chronic liver failure who have prior decompensation[J]. J Gastroenterol Hepatol . 2015 (4)
  • 8Xiang-Rui Ma,Ya-Ling Tang,Ming Xuan,Zheng Chang,Xiao-Yi Wang,Xin-Hua Liang,Fabio Marra.Transplantation of Autologous Mesenchymal Stem Cells for End-Stage Liver Cirrhosis: A Meta-Analysis Based on Seven Controlled Trials[J]. Gastroenterology Research and Practice . 2015
  • 9Konstantina Sargenti,Hanne Prytz,Anna Strand,Emma Nilsson,Evangelos Kalaitzakis.Healthcare‐associated and nosocomial bacterial infections in cirrhosis: predictors and impact on outcome[J]. Liver Int . 2015 (2)
  • 10Danai Agiasotelli,Alexandra Alexopoulou,Larisa Vasilieva,Spyros P. Dourakis.Low free T 3 levels are related to early mortality in patients with decompensated cirrhosis and acute-on chronic liver failure[J]. Journal of Hepatology . 2014 (6)

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