摘要
目的 探讨血清CXC趋化因子配体12(CXCL12)、细胞角蛋白18裂解片段(CCCK-18)水平检测在急性脑出血(ACH)患者预后评估中的价值。方法 选取2017年9月—2021年9月收治的168例ACH患者为研究对象,治疗后随访6个月。统计患者预后情况,分析影响ACH患者预后的因素,分析CXCL12、CCCK-18水平预测ACH患者预后的价值。结果 168例ACH患者中有41例出现预后不良情况,剩余127例患者预后良好。Logistic多因素回归分析显示CXCL12、CCCK-18、美国国立卫生研究院卒中量表(NIHSS)评分是影响ACH患者预后的独立因素(P<0.05)。ROC曲线分析显示,CXCL12、CCCK-18及二者联合预测ACH患者预后不良AUC分别为0.759、0.733、0.892。结论 ACH患者预后不良风险高,CXCL12、CCCK-18与ACH患者病预后有关,二者联合预测ACH患者预后效能良好,具有临床推广价值。
Objective To explore the value of serum CXC chemokine ligand 12(CXCL12)and cytokeratin 18 cleavage fragment(CCCK-18)levels in the prognostic evaluation of patients with acute cerebral hemorrhage(ACH).Methods A total of 168 ACH patients admitted to the Shuyang Hospital,Xuzhou Medical University were selected as the research subjects from September 2017 to September 2021,and they were followed up for 6 months after treatment.The prognosis of patients was counted,the factors affecting the prognosis of ACH patients were analyzed,and the value of CXCL12 and CCCK-18 levels in predicting the prognosis of ACH patients was analyzed.Results 41 had a poor prognosis,and the remaining 127 patients had a good prognosis among 168 ACH patients.Logistic multivariate regression analysis showed that CXCL12,CCCK-18,and National Institutes of Health Stroke Scale Score(NIHSS)were independent factors affecting the prognosis of ACH patients(P<0.05).ROC curve analysis showed that CXCL12,CCCK-18 and the combination of CXCL12,CCCK-18 and the combination of the two predicted the poor prognosis of ACH patients with AUC of 0.759,0.733,0.892,respectively.Conclusion ACH patients have a high risk of poor prognosis.CXCL12 and CCCK-18 are related to the prognosis of ACH patients.The combination of the two predicts the prognosis of ACH patients and has clinical promotion value.
作者
鲍俊杰
王光胜
耿德勤
顾汉沛
周大志
BAO Junjie;WANG Guangsheng;GENG Deqin;GU Hanpei;ZHOU Dazhi(Department of Neurology,Shuyang Hospital,Xuzhou Medical University,Suqian Jiangsu 223600,China)
出处
《中国急救复苏与灾害医学杂志》
2023年第5期629-632,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
基金
江苏省卫生健康委科研项目(编号:Z2019032)。
关键词
急性脑出血
CXC趋化因子配体12
细胞角蛋白18裂解片段
预后
Acute cerebral hemorrhage
CXC chemokine ligand 12
Cytokeratin 18 cleavage fragment
Prognosis论著临床急诊急救中国急救复苏与灾害医学杂志2023年5月第18卷第5期Chin J Emerg Resusc Disaster Med,May 2023,Vol.18 No.5
