摘要
目的:系统评价独活寄生汤干预中老年膝骨关节炎的临床疗效和安全性。方法:通过计算机检索中、外文数据库(中国知网CNKI、万方、维普、Pubmed、Embase、Cochrane Library)以及手动检索相关期刊文献中有关独活寄生汤干预中老年膝骨关节炎的随机对照试验。检索时间为自建库至2022年1月。由两名独立的研究员使用Cochrane风险偏倚评估工具评估其纳入研究的质量后,再使用Revman 5.4软件对其进行Meta分析。结果:共纳入11篇文献,其文献质量均存在高度偏倚风险。总共1057例患者,试验组有529例患者使用独活寄生汤干预,对照组有528例患者单纯使用非类固醇抗炎药或单纯的使用软骨保护剂(硫酸氨基葡萄糖类)或单纯的使用关节腔内注射药物(玻璃酸钠类)或单纯的常规西药治疗。Meta分析结果显示,与对照组比较,试验组使用独活寄生汤干预中老年膝骨关节炎在提升临床总有效率[OR=4.66,95%CI(3.02,7.22),P<0.00001]、降低视觉模拟评分(VAS)[MD=-1.43,95%CI(-1.98,-0.88),P<0.00001]更有优势,并且降低关节液中白介素6(IL-6)[SMD=-1.49,95%CI(-2.16,-0.83),P<0.0001]、肿瘤坏死因子[SMD=-2.55,95%CI(-3.53-1.57),P<0.0001]更低,两组不良反应发生率[OR=0.37,95%CI(0.101.38),Z=1.48,P=0.14]无显著差异。结论:独活寄生汤干预中老年膝骨关节炎可降低其炎性因子含量以缓解膝关节疼痛,从而提高其治疗的总有效率,最终改善膝关节的功能活动。
Objective:To evaluate the clinical efficacy and safety of Duhuo Jisheng Decoction in intervention of middleaged and elderly patients with knee osteoarthritis by using a Meta analysis system.Methods:Computer search of Chinese and foreign language databases(CNKI,WANFANG,VIP,Pubmed,Embase,Cochrane Library)and manual search of related journals and literature on the intervention of Duhuojisi Decoction in middle-aged and elderly knee osteoarthritis randomized controlled trials.The search time is from self-built database to January 2022.Two independent researchers used the Cochrane risk bias assessment tool to assess the quality of the included studies,and then used Revman 5.4 software to conduct a meta-analysis.Results:ll literatures were included,and the quality of their literatures was at high risk of bias.1057 patients,529 patients in the experimental group were treated with Duhuo Jisheng Decoction,and 528 patients in the control group were treated with non-steroidal anti-inflammatory drugs or chondroprotective agents(glucosamine sulfate)alone,as well as those in the control group.Intra-articular injection of drugs(sodium hyaluronate)and simple conventional western medicine treatment.Meta-analysis results showed that compared with the control group,the trial group's use of Duhuo Jisheng Decoction to intervene in knee osteoarthritis in middle-aged and elderly patients improved the total clinical effective rate[OR=4.66,95%CI(3.02,7.22),P<0.00001]and decreased vision The simulated scoring method(VAS)[MD=-1.43,95%CI(-1.98,-0.88).P<0.00001]is more advantageous.And reduce knee joint fluid interleukin 6(IL-6)[SMD=-1.49,95%CI(-2.16-0.83),P<0.0001],tumor necrosis factor[SMD=-2.55,95%CI(-3.53-1.57),P<0.00001]is lower,and the incidence of adverse reactions between the two groups[OR=0.37,95%CI(0.101.38),Z=1.48,P=0.14]has no significant difference.Conclusion:The intervention of Duhuo Jisheng Decoction on knee osteoarthritis in middle-aged and elderly people can relieve knee joint pain by reducing the content of inflammatory factors,thereby increasing the total effective rate of its treatment,and ultimately improving the functional activities of the knee joint.
作者
肖可
王攀
岳鹏
唐成剑
周长征
Xiao Ke;Wang Pan;Yue Peng;Tang Chengjian;Zhou Changzheng(The First Hospital Affiliated to Hunan University of Chinese Medicine,Changsha 410007,China;Hunan University of Chinese Medicine,Changsha 410208,China)
出处
《亚太传统医药》
2023年第5期187-193,共7页
Asia-Pacific Traditional Medicine
基金
湖南省卫生健康委科研课题(2021104071103,20201807)
湖南省中医药科研计划项目(2021251)
湖南中医药大学校级科研基金项目(ZYYDX201728)。
关键词
膝骨关节炎
独活寄生汤
中老年人
META分析
Knee Osteoarthritis
Duhuo Jisheng Decoction
Middle-Aged and Elderly People
Meta Analysis
