摘要
目的探索中国9个长寿地区≥65岁老年人血浆维生素B_(12)与尿酸水平的关联。方法以2017—2018年“中国老年健康生物标志物队列研究”项目中≥65岁老年人血浆维生素B_(12)和尿酸数据未缺失者为研究对象。通过问卷调查和体格检查,收集调查对象的社会人口学特征、生活方式和膳食摄入及健康状况等信息;采集空腹静脉血以检测血浆维生素B_(12)、尿酸等指标水平。采用多元线性回归模型分析血浆维生素B_(12)水平与尿酸水平的关联,采用限制性立方样条拟合线性回归模型描述血浆维生素B_(12)水平与尿酸水平关联趋势,采用多元logistic回归模型分析不同四分位数血浆维生素B_(12)水平和高尿酸血症关联。结果共纳入2471名老年人,年龄为(84.88±19.76)岁,女性1291名(52.25%),血浆维生素B_(12)水平的M(Q_(1),Q_(3))为294(203,440)pg/ml,血浆尿酸水平为(341.01±90.46)μmol/L,共有422例(17.08%)老年人患高尿酸血症。多元线性回归模型分析结果显示,调整协变量后,血浆维生素B_(12)与尿酸水平呈正向关联(P<0.05),血浆维生素B_(12)每增加一个四分位数间距(237 pg/ml),血浆尿酸水平增加6.36(95%CI:2.00~10.72)μmol/L。限制性立方样条分析显示,对数转换后血浆维生素B_(12)与尿酸水平呈正向线性关联(P<0.001)。结论中国9个长寿地区≥65岁老年人血浆维生素B_(12)与尿酸水平呈正向关联。
Objective To investigate the association of plasma vitamin B_(12)level with plasma uric acid level among the elderly over 65 in 9 longevity areas of China.Methods The elderly over 65 years old with complete information on plasma vitamin B_(12)and plasma uric acid from Healthy Aging and Biomarkers Cohort Study(2017 to 2018)were recruited in this study.Information on socio-demographic characteristics,life styles,diet intake,and health status were collected by questionnaire and physical examination;and fasting venous blood was collected to detect the levels of plasma vitamin B_(12),uric acid and other indicators.Multiple linear regression models were used to analyze the association of plasma vitamin B_(12)level per interquartile range increase with plasma uric acid level.The association trend of plasma vitamin B_(12)level with plasma uric acid level was described by restrictive cubic splines fitting multiple linear regression model.Multiple logistic regression models were used to analyze the association of plasma vitamin B_(12)level stratified by quartiles with hyperuricemia.Results A total of 2471 participants were finally included in the study,the age was(84.88±19.76)years old,of which 1291(52.25%)were female.The M(Q_(1),Q_(3))level of plasma vitamin B_(12)was 294(203,440)pg/ml and the plasma uric acid level was(341.01±90.46)μmol/L.A total of 422 participants(17.08%)were defined with hyperuricemia.The results of multiple linear regression model showed that there was a positive association of plasma vitamin B_(12)level with plasma uric acid level after adjustment for covariates(P<0.05).An IQR increase in plasma vitamin B_(12)(237 pg/ml)was associated with a 6.36(95%CI:2.00-10.72)μmol/L increase in the plasma uric acid level.The restrictive cubic splines curve showed a positive linear association of log-transformed plasma vitamin B_(12)with uric acid level(P<0.001).Conclusion There is a positive association of plasma vitamin B_(12)level with plasma uric acid level among the elderly over 65 years old in 9 longevity areas of China.
作者
郑栩琳
吴兵
曲英莉
陈晨
王君
李峥
裘一丹
章正
李方玙
叶丽红
周锦辉
魏源
吉赛赛
吕跃斌
施小明
Zheng Xulin;Wu Bing;Qu Yingli;Chen Chen;Wang Jun;Li Zheng;Qiu Yidan;Zhang Zheng;Li Fangyu;Ye Lihong;Zhou Jinhui;Wei Yuan;Ji Saisai;Lyu Yuebin;Shi Xiaoming(Center for Global Health,School of Public Health,Nanjing Medical University,Nanjing 211166,China;China CDC Key Laboratory of Environment and Population Health/National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China;Department of Environmental Epidemiology,National Institute of Environmental Health,Chinese Center for Disease Control and Prevention,Beijing 100021,China)
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2023年第5期634-640,共7页
Chinese Journal of Preventive Medicine
基金
国家自然科学基金(82025030,81941023)
中国营养学会科研基金——振东国人体质与健康专项基金(CNS-ZD2020-19)。
