摘要
目的总结分析湖南省儿童医院(以下简称“我院”)患儿使用注射用炎琥宁所致药品不良反应(ADR)的发生情况,促进儿童临床安全合理用药。方法采用回顾性分析方法,对我院2006年1月至2020年12月使用注射用炎琥宁治疗后发生的132例ADR报告进行统计分析,同时结合鱼骨图对ADR的发生进行根本原因分析,并对用药进行合理性评价。结果132例注射用炎琥宁所致ADR主要发生于0~3岁婴幼儿;最主要临床表现为皮肤及附件损害;严重ADR 12例,占9.09%。ADR的发生与超适应证、超疗程用药、静脉用药浓度与滴速及患者自身因素等相关。结论临床应加强注射用炎琥宁的临床合理用药,及时监测与干预,减少不良反应的发生,提高儿童用药安全。
Objective To summarize and analyze the occurrence of adverse drug reactions(ADR)caused by children with Yanhuning for injection in Hunan Children’s Hospital(“our hospital”for short),and to promote the safe and rational use of drugs in children’s clinics.Methods A retrospective analysis method was used to statistically analyze 132 reports of ADR that occurred after treatment with Yanhuning for injection in our hospital from January 2006 to December 2020,as well as to analyze the root causes of ADR in combination with fishbone diagrams and to evaluate the rationality of drug use.Results ADR of 132 cases caused by Yanhuning for injection occurred mainly in infants and children aged 0-3 years;the most important clinical manifestations were skin and adnexal damage;12 cases(9.09%)were severe ADR.the occurrence of ADR was related to super-indication,super-therapeutic dosing,intravenous drug concentration and drip rate,and patients’own factors.Conclusion The clinic should strengthen the clinical rational use of Yanhunin for injection,timely monitoring and intervention to reduce the occurrence of adverse reactions and improve the safety of drug use in children.
作者
王方杰
王婷
何莉梅
罗芳梅
蒋志平
WANG Fangjie;WANG Ting;HE Limei;LUO Fangmei;JIANG Zhiping(Department of Pharmacy,Hunan Children’s Hospital,Hunan Province,Changsha410007,China)
出处
《中国医药导报》
CAS
2023年第14期65-69,共5页
China Medical Herald
基金
湖南省卫生健康委科研计划项目(20200092)。
关键词
注射用炎琥宁
儿童
鱼骨图
不良反应
Yanhuning for injection
Children
Fishbone diagram
Adverse reaction
