摘要
目的分析山东中医药大学附属医院治疗各年龄段的局灶性子宫腺肌病(AM)患者的用药规律,以拓展该病保守性及阶段性治疗的思路。方法收集2012年1月至2017年12月于山东中医药大学附属医院门诊就诊的局灶性AM患者资料,应用频数分析、多尺度骨干网络分析等数据挖掘方法,总结各年龄段的人群分布、高频用药、功效占比及核心处方。结果局灶性AM的好发年龄为30~49岁。得到不同年龄段的核心处方:20~<30岁为醋延胡索、醋香附、蒲黄、当归、川芎、赤芍、白芍、盐小茴香;30~<40岁为醋香附、醋延胡索、蒲黄、当归、川芎、白芍、益母草、连翘、盐小茴香;40~<50岁为醋香附、醋延胡索、益母草、川芎、白芍、蒲黄、牡蛎、当归、党参;50~55岁为牡蛎、蒲黄、党参、生地黄、炙黄芪、黄柏、墨旱莲、酒女贞子、知母、醋香附。结论局灶性AM患者发病年龄具有年轻化趋势。治疗局灶性AM应在活血化瘀、理气止痛的基础上,根据不同年龄段的病机差异,佐以温里散寒、清热解毒、补气养血、益肾滋阴、化瘀止血等治法,拓展了该病保守性及阶段性治疗的思路。
Objective To analyze the medication rule of focal adenomyopathy(AM)patients of different ages in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,so as to expand the idea of conservative and phased treatment of AM.Methods Data of focal AM patients in the outpatient department of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2012 to December 2017 were collected.Frequency analysis,multi-scale backbone network analysis,and other data mining methods were used to summarize the population distribution,high-frequency drug use,efficacy ratio,and core prescriptions of each age group.Results The age of onset was highest in patients aged 30-49 years.Core prescriptions for different age groups were obtained.The core prescriptions of 20-<30 years old were stir-frying with vinegar Corydalis Rhizoma,stir-frying with vinegar Cyperi Rhizoma,Typhae Pollen,Angelicae Sinensis Radix,Chuanxiong Rhizoma,Paeoniae Radix Rubra,Paeoniae Radix Alba,stir-frying with salt Foeniculi Fructus;the core prescriptions of 30-<40 years old were stir-frying with vinegar Cyperi Rhizoma,stir-frying with vinegar Corydalis Rhizoma,Typhae Pollen,Angelicae Sinensis Radix,Chuanxiong Rhizoma,Paeoniae Radix Alba,Leonuri Herba,Forsythiae Fructus,stir-frying with salt Foeniculi Fructus;the core prescriptions of 40-<50 years old were stir-frying with vinegar Cyperi Rhizoma,stir-frying with vinegar Corydalis Rhizoma,Leonuri Herba,Chuanxiong Rhizoma,Paeoniae Radix Alba,Typhae Pollen,Ostreae Concha,Angelicae Sinensis Radix,Codonopsis Radix;the core prescriptions of 50-55 years old were Ostreae Concha,Typhae Pollen,Codonopsis Radix,Rehmanniae Radix,stir-frying Astragali Radix,Phellodendri Chinensis Cortex,Ecliptae Herba,stir-frying with wine Ligustri Lucidi Fructus,Anemarrhenae Rhizoma,stir-frying with vinegar Cyperi Rhizoma.Conclusion The onset age of focal AM patients tends to be younger.The treatment of focal AM should be based on activating blood circulation to dissipate blood stasis,regulating qi and relieving pain,and according to the pathogenesis differences of different age groups,with the treatment of warming interior and dispersing cold,clearing heat and detoxifying,replenishing qi and nourishing blood,tonifying kidney and nourishing yin,removing blood stasis and stopping bleeding,etc.,to expand the conservative and phased treatment of the disease.
作者
丁楠
刘双
师伟
刘志勇
赵若曦
DING Nan;LIU Shuang;SHI Wei;LIU Zhiyong;ZHAO Ruoxi(Yueyang Clinical Medical College,Shanghai University of Traditional Chinese Medicine,Shanghai201203,China;the First Clinical Medical College,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan250014,China;Department of Gynecology,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan250014,China;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan250355,China)
出处
《中国医药导报》
CAS
2023年第14期132-136,共5页
China Medical Herald
基金
国家自然科学基金面上项目(81873330)
山东省泰山学者工程项目(tsqn201909185)。
关键词
局灶性子宫腺肌病
数据挖掘
中药处方
用药规律
Focal adenomyosis
Data mining
Chinese medicine prescription
Medication rule
