摘要
目的分析腹腔镜下空回肠侧侧吻合术对2型糖尿病患者血糖及血脂代谢的影响。方法对2018年1月至2019年2月吉林省一汽总医院诊断2型糖尿病并接受腹腔镜下空肠回肠侧侧吻合术患者52例的临床资料进行回顾性分析,分析术前及术后3年总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、糖化血红蛋白(HbA1c)的变化情况。结果52例患者中,术后3年血糖控制完全缓解23例,部分缓解11例,明显改善8例,无效10例,总体有效率80.77%。2型糖尿病患者预防动脉粥样硬化性心血管疾病(ASCVD)高危人群的控制目标中,术后LDL-C<2.6 mmol/L的达标率(74.19%vs 12.90%),TG<1.7 mmol/L的达标率(77.42%vs 48.39%)较术前显著提高(P<0.05)。对于极高危人群的主要目标中,LDL-C<1.8 mmol/L的达标率术后较术前显著提高(71.43%vs 7.14%,P<0.01)。术后随访3年,TC、TG、LDL-C、HbA1c水平均较术前降低(P<0.01)。结论腹腔镜下空回肠侧侧吻合术治疗2型糖尿病可以有效缓解血糖及血脂代谢异常。
Objective To analyze the effect of laparoscopic side-to-side jejunoileal anastomosis on blood glucose and lipid metabolism in type 2 diabetes mellitus(T2DM)patients.Methods The clinical data of 52 patients with T2DM diagnosed in Jilin Province FAW Hospital from January 2018 to February 2019 who underwent laparoscopic side-to-side jejunoileal anastomosis were retrospectively analyzed.The changes of total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),and glycosylated hemoglobin(HbA1c)before and 3 years after the operation were analyzed.Results Among the 52 patients,23 had complete remission,11 had partial remission,8 had significant improvement,and 10 had no effect at 3 years after surgery.The overall effective rate of blood glucose control was 80.77%.In the control goal of preventing atherosclerosis cardiovascular disease(ASCVD)high-risk groups in T2DM patients,the rate of reaching the target of LDL-C<2.6 mmol/L(74.19%vs 12.90%)and TG<1.7 mmol/L(77.42%vs 48.39%)after surgery were significantly higher than those before surgery(P<0.05).Among the main targets for extremely high-risk groups,the rate of reaching the standard for LDL-C<1.8 mmol/L after surgery was significantly higher than that before surgery(71.43%vs 7.14%,P<0.01).After 3 years of follow-up,the levels of TC,TG,LDL-C,and HbA1c were lower than those before surgery(P<0.01).Conclusion Laparoscopic side-to-side jejunoileal anastomosis can effectively alleviate the abnormal metabolism of blood glucose and lipids in the treatment of T2DM.
作者
王中会
吕洪亮
孙铁梁
戴春雷
杨聚鹏
刘明
谷洋
张红裔
金虎
WANG Zhonghui;LYU Hongliang;SUN Tieliang;DAI Chunlei;YANG Jupeng;LIU Ming;GU Yang;ZHANG Hongyi;JIN Hu(The Second General Surgery Department,Jilin Province General FAW Hospital,Changchun,Jilin 130011,China)
出处
《中国临床研究》
CAS
2023年第5期661-664,共4页
Chinese Journal of Clinical Research
基金
吉林省卫健委青年科技骨干培养计划(2019Q040)
吉林省自然科学基金(20200201585JC)。
关键词
空回肠侧侧吻合术
2型糖尿病
血糖
血脂
总胆固醇
三酰甘油
高密度脂蛋白胆固醇
低密度脂蛋白胆固醇
糖化血红蛋白
Side-to-side jejunoileal anastomosis
Type 2 diabetes mellitus
Blood glucose
Blood lipid
Total cholesterol
Triacylglycerol
High-density lipoprotein cholesterol
Low-density lipoprotein cholesterol
Glycosylated hemoglobin
