摘要
最近发现的眼胶质淋巴系统更新了临床对眼内循环的认知,其是一个由神经胶质细胞终足上水通道蛋白4(AQP4)驱动并依赖视网膜动、静脉周围间隙的房水-组织液交换系统,最终起到将β淀粉样蛋白等神经毒性物质排出眼外的作用。本文综述了眼胶质淋巴系统的组成和功能,描述了生理状态下该系统具体的循环路径及其在青光眼、视盘水肿、Terson综合征(TS)等疾病过程中的障碍机制,并提出未来可确定眼胶质淋巴系统具体调控环节,针对具体环节改善该系统的功能,如利用中药多靶点、多途径的优势促进眼内代谢废物的清除,这将有机会为青光眼等诸多眼病和一些中枢神经系统疾病的治疗带来希望。
Recent discovered ocular glymphatic system,which is facilitated by aquaporin-4(AQP4)and dependent on the exchange system of aqueous humor-tissue fluid in the perivascular space of retinal arterial and venous,ultimately acts as the role of expelling neurotoxic substances such as beta-amyloid out of the eye,has updated our knowledge of intraocular circulation.This paper reviews the composition and function of ocular glymphatic system,describes its specific circulatory paths in the physiological state and mechanism of impairment in the progression of glaucoma,optic disc edema,Terson syndrome and other diseases,In the future,we can identify the specific regulatory links of the ocular glymphatic system and improve the function of the system,such as using the advantages of multiple targets and multiple pathways of traditional Chinese medicine to promote the removal of metabolic wastes in the eye,which will bring hope to the treatment of many eye diseases such as glaucoma and some central nervous system diseases.
作者
祝光宇
程雨欣
路雪婧
ZHU Guangyu;CHENG Yuxin;LU Xuejing(Eye School of Chengdu University of TCM,Chengdu 610075,China;Key Laboratory of Sichuan Province Ophthalmopathy Prevention&Cure and Visual Function Protection with TCM,Chengdu 610075,China;Ineye Hospital of Chengdu University of TCM,Chengdu 610075,China)
出处
《中国全科医学》
CAS
北大核心
2023年第26期3330-3334,共5页
Chinese General Practice
基金
国家自然科学基金面上项目(82174444)。
