摘要
“一气周流”是中医经典理论,其核心思想认为中气(脾胃之气)是整个气机运转的枢纽。脾胃虚弱,肝气郁结,水谷精微运化疏泄失常,日久痰浊瘀血内生,积聚于血管,引起代谢综合征血管内皮损伤。临床及实验研究均证实健脾疏肝方剂柴芪汤对代谢综合征及相关血管内皮损伤具有较好改善作用。细胞焦亡是一种促炎性程序性细胞死亡方式,在血管内皮炎症反应中具有重要作用,这一过程类似于中医“痰瘀浊毒”的积聚。基于“一气周流”理论探讨细胞焦亡与代谢综合征血管内皮损伤的机制,为中医经典理论和中医药防治代谢综合征血管并发症提供理论依据。
One qi circulation is a classical theory of traditional Chinese medicine(TCM).According to this theory,the qi in spleen and stomach is the hub of qi movement around the whole body.The deficiency of spleen and stomach and stagnation of liver qi lead to the transportation and transformation disorders of water and grain and the obstructed qi flow,the lingering of which causes the accumulation of phlegm and stasis in the blood vessels and further vascular endothelial injury in metabolic syndrome.Clinical trials have confirmed that Chaiqi Decoction with the effects of invigorating spleen and soothing liver can ameliorate metabolic syndrome and related vascular endothelial injury.Pyroptosis,a pro-inflammatory programmed cell death,plays a key role in vascular endothelial inflammation.This process is similar to the accumulation of phlegm,stasis,turbidity,and toxin in TCM.Based on the theory of one qi circulation,this paper elaborates on the mechanism of pyroptosis and vascular endothelial injury in metabolic syndrome,aiming to provide a theoretical basis for the prevention and treatment of vascular complications in metabolic syndrome with TCM.
作者
徐帅
赵玉清
陈恂
卞昊宇
杨一点
张立平
XU Shuai;ZHAO Yuqing;CHEN Xun;BIAN Haoyu;YANG Yidian;ZHANG Liping(Beijing University of Chinese Medicine,Beijing 100029,China;Xiyuan Hospital of China Academy of Chinese Medical Sciences,Beijing 100091,China)
出处
《世界中医药》
CAS
2023年第10期1411-1414,1419,共5页
World Chinese Medicine
基金
国家自然科学基金项目(82104934)
北京市自然科学基金项目(7212181)
北京中医药大学重点攻关项目(2020-JYB-ZDGG-138)。
关键词
“一气周流”理论
焦亡
代谢综合征
血管内皮损伤
中气
气机升降
中医经典理论
脾虚肝郁
Theory of one qi circulation
Pyroptosis
Metabolic syndrome
Vascular endothelial injury
Qi in spleen and stomach
Qi movement
Classical theory of traditional Chinese medicine
Spleen deficiency and liver depression
