摘要
目的 探讨缺血性脑卒中(IS)认知功能障碍(CI)与血清同型半胱氨酸(Hcy)、淀粉样蛋白A(SAA)、Tau蛋白的关系。方法 选择本院2020年2月~2022年2月110例IS患者为研究对象,调查CI发生情况以及性别、年龄、合并症等病历资料,检测血清Hcy、SAA、Tau蛋白水平。比较CI组、非CI组患者病历资料以及血清指标,采用多因素分析其与IS后CI的关系。结果 110例IS患者检出CI 52例,检出率47.27%;CI组、非CI组年龄、教育程度、美国国立卫生研究院脑卒中量表(NIHSS)评分、梗死部位涉及额叶或颞叶差异具有统计学意义(P<0.05),两组性别、婚姻、居住地差异无统计学意义(P>0.05);CI组血清Hcy、SAA、Tau蛋白水平高于非CI组。多因素分析显示,小学及以下文化水平、梗死部位涉及额叶或颞叶、NIHSS评分、血清Hcy、SAA、Tau蛋白水平是IS后CI的危险因素。结论 IS后CI发生率较高,危险因素涉及文化程度、梗死部位、神经功能,且血清Hcy、SAA、Tau蛋白水平高也可增加CI风险。
Objective To discuss the relationship between cognitive impairment(CI)and serum homocysteine(Hcy),amyloid A(SAA)and Tau protein in ischemic stroke(IS)patients.Methods A total of 110 IS patients in our hospital from February 2020 to February 2022 were selected as the research subjects.The occurrence of CI and medical records such as gender,age,and comorbidities were investigated.Serum Hcy,SAA and Tau protein levels were detected.The medical records and serum indexes of patients in CI group and non-CI group were compared.Multivariate analysis was used to analyze its relationship with post-IS CI.Results 52 cases of CI were detected in 110 IS patients,and the detection rate was 47.27%.There were statistically significant differences in age,education level,National Institutes of Health Stroke Scale(NIHSS)score,and infarct site involving frontal or temporal lobe between CI group and non-CI group(P<0.05).There was no significant difference in gender,marriage and residence between the two groups(P>0.05).The levels of serum Hcy,SAA and Tau protein in the CI group were higher than those in the non-CI group.Multivariate analysis showed that the education level of primary school and below,the infarct site involving the frontal or temporal lobe,NIHSS score,serum Hcy,SAA,and Tau protein levels were the risk factors for CI after IS.Conclusion The incidence of CI is higher after IS,and the risk factors include educational level,infarct site,and neurological function,and high levels of serum Hcy,SAA,and Tau protein can also increase the risk of CI.
作者
曹金娟
CAO Jinjuan(Department of Neurology,Kaifeng Central Hospital,Kaifeng 475000,China)
出处
《国际精神病学杂志》
2023年第2期280-283,共4页
Journal Of International Psychiatry
